Innovative Plant Exosome Delivery System for Enhancing Antiaging Potency on Skin

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-02-24 DOI:10.1021/acsabm.4c0169110.1021/acsabm.4c01691

Wei Wei, Xiaobing Ren, Fan Yi, Xuhui Zhang, Jiali Hou, Zhenxing Zhang, Liqian Yuan, Li Li* and Qi Gao*,

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Abstract

Plant exosomes, small vesicles released by plant cells that contain various bioactive molecules, have garnered great attention for their potential applications in medicine, yet their delivery applications for skincare remain underexploited. Resveratrol (RES), renowned for its remarkable antiaging properties, faces challenges in transdermal absorption due to the stratum corneum barrier, hindering its efficacy. To address this, we developed a delivery system incorporating RES-loaded plant (Leontopodium alpinum) exosome (LEOEXO@RES). Evaluation through both in vitro and in vivo experiments demonstrated LEOEXO@RES’s enhanced delivery of bioactive compounds and multifaceted skincare impact. Specifically, this approach not only promoted environmentally responsible waste reuse but also achieved harmonious synergy between LEOEXO carriers and RES, enhancing their overall efficacy. The LEOEXO@RES effectively ameliorated inflammation levels and inhibited cellular senescence, highlighting its promising potential in antiaging skincare applications.

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创新植物外泌体输送系统增强皮肤抗衰老能力

植物外泌体是由植物细胞释放的含有多种生物活性分子的小泡，因其在医学上的潜在应用而受到广泛关注，但其在皮肤护理方面的应用仍未得到充分开发。白藜芦醇（Resveratrol， RES）以其显著的抗衰老特性而闻名，但由于角质层的屏障，白藜芦醇在透皮吸收方面面临挑战，阻碍了其功效。为了解决这个问题，我们开发了一种含有res负载植物（Leontopodium alpinum）外泌体的递送系统（LEOEXO@RES）。通过体外和体内实验的评估表明LEOEXO@RES增强了生物活性化合物的传递和多方面的护肤影响。具体而言，该方法不仅促进了对环境负责的废物再利用，而且实现了LEOEXO载体与RES之间的和谐协同，提高了其整体功效。LEOEXO@RES有效改善炎症水平，抑制细胞衰老，突出其在抗衰老护肤应用中的潜力。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.