Successful Liver Transplantation After Achieving Complete Clinical Remission of Hepatocellular Carcinoma With Combination Therapy of Immune Checkpoint Inhibitors and Targeted Agents: A Case Report

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-03-14 DOI:10.1016/j.transproceed.2025.02.041

Shaobo Zhang , Shugeng Zhang

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引用次数: 0

Abstract

Immunotherapy, primarily with immune checkpoint inhibitors, has become pivotal in the treatment of advanced hepatocellular carcinoma (HCC), leading to significant tumor burden reduction. However, its applicability in liver transplantation remains controversial. Due to the potential risks of rejection limiting large-scale clinical trials and the incomplete understanding of underlying mechanisms, whether transplant recipients can benefit from immunotherapy remains uncertain. This report describes the application of immunotherapy in liver transplantation, wherein two patients achieved complete tumor remission after receiving immunotherapy combined with other treatments before transplantation, enabling successful liver transplantation surgeries. Additionally, one patient received combination therapy with tislelizumab and lenvatinib before transplantation (Case 2), representing the first reported case utilizing this combination therapy as a bridging treatment before LT.

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免疫检查点抑制剂和靶向药物联合治疗肝细胞癌临床完全缓解后成功进行肝移植：1例报告

免疫疗法，主要是免疫检查点抑制剂，已经成为晚期肝细胞癌（HCC）治疗的关键，导致肿瘤负担显著减轻。然而，其在肝移植中的适用性仍存在争议。由于排斥反应的潜在风险限制了大规模的临床试验和对其潜在机制的不完全理解，移植受体是否能从免疫治疗中获益仍然不确定。本报告描述了免疫治疗在肝移植中的应用，其中两例患者在移植前接受免疫治疗联合其他治疗后肿瘤完全缓解，使肝移植手术成功。此外，一名患者在移植前接受了tislelizumab和lenvatinib的联合治疗（病例2），这是首次报道的在移植前使用该联合治疗作为桥接治疗的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.