A Skin Biopsy of the Abdominal Wall Without a Rash Is Safe and Effective in the Diagnosis of Systemic Amyloidosis.

IF 1.1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI:10.1097/DAD.0000000000002862

Koya Obara, Kyoko Baba

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引用次数: 0

Abstract

Abstract: The diagnosis of systemic amyloidosis is decided through histologic materials from biopsy from different organs. This is a retrospective study from the institutional database of our hospital and consisted of patients to being judged to need skin biopsy for the purpose of diagnosing systemic amyloidosis visiting dermatology between April 2005 and August 2022. A total of 30 patients underwent the skin biopsy of dermis and fatty tissue on abdominal wall without rash and a total of 36 specimens were obtained. A total of 14 of these specimens showed amyloid deposition histologically. Among the 14 specimens, amyloid immunoglobin light chain amyloidosis in 8 samples (57.1%) was the most diagnosed, the others being wild-type amyloid transthyretin amyloidosis in 5 samples (35.8%) and amyloid A amyloidosis in 1 sample (7.1%). The skin biopsy has an 87.5% (14 of 16) sensitivity and 100% (20 of 20) specificity, with 12.5% (2 of 16) false negatives and 0% (0 of 20) false positives in diagnosis of systemic amyloidosis. Skin biopsy from normal abdominal wall skin to evaluate dermis and fatty tissue is a safe, sensitive, and specific procedure to the diagnosis of systemic amyloidosis.

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摘要：系统性淀粉样变性的诊断是通过不同器官活检的组织学材料来决定的。本研究是一项回顾性研究，来自我院的机构数据库，研究对象是2005年4月至2022年8月期间到皮肤科就诊的被判断为需要进行皮肤活检以诊断系统性淀粉样变性的患者。共有30名患者接受了腹壁真皮和脂肪组织的皮肤活检，无皮疹，共获得36份标本。其中 14 份标本在组织学上显示有淀粉样蛋白沉积。在这 14 份标本中，8 份标本（57.1%）确诊为淀粉样免疫球蛋白轻链淀粉样变性，其他 5 份标本（35.8%）确诊为野生型淀粉样转hyretin淀粉样变性，1 份标本（7.1%）确诊为淀粉样 A 淀粉样变性。在诊断全身性淀粉样变性病时，皮肤活检的敏感性为 87.5%（16 例中的 14 例），特异性为 100%（20 例中的 20 例），假阴性率为 12.5%（16 例中的 2 例），假阳性率为 0%（20 例中的 0 例）。从正常腹壁皮肤进行皮肤活检以评估真皮和脂肪组织是诊断全身性淀粉样变性病的一种安全、敏感和特异的方法。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians