Temporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest

IF 6.5 1区医学 Q1 CRITICAL CARE MEDICINE

Resuscitation Pub Date : 2025-03-12 DOI:10.1016/j.resuscitation.2025.110578

Jonathan Tam , Cecelia Ratay , Laura Faiver , Patrick J. Coppler , Micaila Baroffio , Mikaela Mohardt , Nicholas Case , Clifton Callaway , Jonathan Elmer , University of Pittsburgh Post-Cardiac Arrest Service

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引用次数: 0

Abstract

Introduction

Frailty is associated with mortality and functional outcome after cardiac arrest. Temporalis muscle thickness (TMT) is a measure of sarcopenia, which represents one dimension of frailty. We assessed the correlation between TMT, measured on head computed tomography (CT), and Clinical Frailty Scale (CFS) in patients resuscitated from cardiac arrest.

Methods

We enrolled adults resuscitated from cardiac arrest who had a head CT obtained within 48 h of collapse. Study investigators prospectively obtained data to determine pre-arrest CFS and blinded investigators measured TMT. We calculated Spearman rank-order correlation to assess the relationship between TMT and CFS. We also performed multivariable regression adjusting for confounders of frailty and sarcopenia.

Results

We enrolled 50 subjects with median CFS 4 [IQR 2–6] and median TMT 6.6 [IQR 5.0–8.9] mm. There was a moderate, negative correlation between TMT and CFS (ρ = −0.52 (p < 0.001)). In linear regression, TMT (R² = 25%) explained more of the variance in CFS than age (R² = 17%).

Conclusions

We found that TMT exhibits a moderate negative correlation with the CFS, supporting TMT as a tool to measure frailty. Measuring TMT in patients with early head CTs after resuscitation from cardiac arrest may allow for characterization of sarcopenia as a dimension of pre-arrest frailty.

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导言虚弱与心脏骤停后的死亡率和功能预后有关。颞肌厚度（TMT）是衡量肌肉疏松症的一个指标，代表了虚弱的一个维度。我们评估了心脏骤停复苏患者头部计算机断层扫描（CT）测量的颞肌厚度与临床虚弱量表（CFS）之间的相关性：我们招募了心脏骤停复苏后在昏迷 48 小时内接受头部 CT 检查的成人。研究调查人员前瞻性地获取数据以确定心跳骤停前的CFS，并由盲法调查人员测量TMT。我们计算了斯皮尔曼秩相关性，以评估 TMT 与 CFS 之间的关系。我们还对虚弱和肌肉疏松症等混杂因素进行了多变量回归调整：我们招募了 50 名受试者，他们的 CFS 中位数为 4 [IQR 2-6]，TMT 中位数为 6.6 [IQR 5.0-8.9]毫米。TMT 与 CFS 呈中度负相关（ρ = -0.52 (p < 0.001)）。在线性回归中，TMT（R2 = 25%）比年龄（R2 = 17%）更能解释 CFS 的变异：结论：我们发现 TMT 与 CFS 呈中度负相关，支持将 TMT 作为衡量虚弱程度的工具。对心脏骤停复苏后进行早期头部 CT 检查的患者进行 TMT 测量，可将肌肉疏松症描述为骤停前虚弱的一个维度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Resuscitation 医学-急救医学

CiteScore

12.00

自引率

18.50%

发文量

556

审稿时长

21 days

期刊介绍： Resuscitation is a monthly international and interdisciplinary medical journal. The papers published deal with the aetiology, pathophysiology and prevention of cardiac arrest, resuscitation training, clinical resuscitation, and experimental resuscitation research, although papers relating to animal studies will be published only if they are of exceptional interest and related directly to clinical cardiopulmonary resuscitation. Papers relating to trauma are published occasionally but the majority of these concern traumatic cardiac arrest.