Bala Sivaraman, Chris Cotter, Kevin Bourque, Steve Briana, Brendan Malloy, Kartik Sundareswaran, Robert Kormos, Staci Jessen Horn, Kirsten Landsgaard, Fred Clubb
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引用次数: 0
Abstract
Extrinsic Outflow Graft Obstruction (EOGO) is a potential complication of durable LVAD therapy characterized by obstructive biodebris accumulation between the outflow graft (OG) and, in the case of HM3, the bend relief (BR). Recent reports have suggested that perforating the HM3 BR may help prevent EOGO. The study objective was to histologically compare the nature and constituency of explanted biologic material from beneath intact HM3 BRs (n=7; with n=3 EOGO) beneath perforated HM3 BRs (n=5), and outside the BR (n=2). Results indicate that material beneath intact BRs (EOGO and non-EOGO samples) is consistently acellular protein (fibrin) or biodebris while material beneath perforated BRs demonstrated collagen and cell infiltration through the perforations, resembling the material found outside graft beyond the BR where EOGO is not observed. Despite the small sample size, this study provides a hypothetical mechanism(s) underlying potential benefits of BR perforations in preventing EOGO by attenuating biodebris accumulation through collagen and cell infiltration.
期刊介绍:
The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.