Neural representation of allegedly sex-specific human body odor compounds

IF 4.7 2区 医学 Q1 NEUROIMAGING
Camille Ferdenzi , Arnaud Fournel , Luca Fantin , Stéphane Richard Ortegón , Cédric Manesse , Nicolas Baldovini , Marc Thévenet , Franck Lamberton , Danielle Ibarrola , Frédéric Faure , Moustafa Bensafi
{"title":"Neural representation of allegedly sex-specific human body odor compounds","authors":"Camille Ferdenzi ,&nbsp;Arnaud Fournel ,&nbsp;Luca Fantin ,&nbsp;Stéphane Richard Ortegón ,&nbsp;Cédric Manesse ,&nbsp;Nicolas Baldovini ,&nbsp;Marc Thévenet ,&nbsp;Franck Lamberton ,&nbsp;Danielle Ibarrola ,&nbsp;Frédéric Faure ,&nbsp;Moustafa Bensafi","doi":"10.1016/j.neuroimage.2025.121114","DOIUrl":null,"url":null,"abstract":"<div><div>Body odors play an important role in nonverbal communication, and particularly in one's attractiveness. However, their central processing remains underexplored, especially as a function of gender. This study aims at identifying the neural networks involved in the processing of two allegedly sex-specific human body odor compounds (3-hydroxy-3-methylhexanoic acid, HMHA, and 3-methyl-3-sulfanylhexan-1-ol, MSH). We hypothesized that i) these body odors would be processed by different brain regions than non-body odors, and that ii) their role in attractiveness, if any, would be indicated by the activation of specific regions and by differential verbal and neurophysiological responses in men and women. Thirty participants (15 men, 15 women) performed a functional Magnetic Resonance Imaging (fMRI) session during which they rated the attractiveness of HMHA, MSH, and 5 non-body odorants. At the end of the session, participants rated all odors on multiple perceptual scales. HMHA activated visual (striate area and occipital gyrus) rather than olfactory brain regions. Men rated HMHA as more masculine than women did, and presented greater neural activity in the superior and medial frontal gyri while women activated the inferior frontal gyrus significantly more than men in response to this odor. MSH was processed as the other non-body odors, and not subject to gender differences. The results suggest that HMHA (not MSH) bears specific social information, resulting in a neural processing outside the main olfactory network. It is also processed differently in men and women, although our findings do not provide clear evidence in favor of relevance for one's attractiveness.</div></div>","PeriodicalId":19299,"journal":{"name":"NeuroImage","volume":"310 ","pages":"Article 121114"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NeuroImage","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1053811925001168","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Body odors play an important role in nonverbal communication, and particularly in one's attractiveness. However, their central processing remains underexplored, especially as a function of gender. This study aims at identifying the neural networks involved in the processing of two allegedly sex-specific human body odor compounds (3-hydroxy-3-methylhexanoic acid, HMHA, and 3-methyl-3-sulfanylhexan-1-ol, MSH). We hypothesized that i) these body odors would be processed by different brain regions than non-body odors, and that ii) their role in attractiveness, if any, would be indicated by the activation of specific regions and by differential verbal and neurophysiological responses in men and women. Thirty participants (15 men, 15 women) performed a functional Magnetic Resonance Imaging (fMRI) session during which they rated the attractiveness of HMHA, MSH, and 5 non-body odorants. At the end of the session, participants rated all odors on multiple perceptual scales. HMHA activated visual (striate area and occipital gyrus) rather than olfactory brain regions. Men rated HMHA as more masculine than women did, and presented greater neural activity in the superior and medial frontal gyri while women activated the inferior frontal gyrus significantly more than men in response to this odor. MSH was processed as the other non-body odors, and not subject to gender differences. The results suggest that HMHA (not MSH) bears specific social information, resulting in a neural processing outside the main olfactory network. It is also processed differently in men and women, although our findings do not provide clear evidence in favor of relevance for one's attractiveness.
求助全文
约1分钟内获得全文 求助全文
来源期刊
NeuroImage
NeuroImage 医学-核医学
CiteScore
11.30
自引率
10.50%
发文量
809
审稿时长
63 days
期刊介绍: NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信