The existing evidence for the use of extracellular vesicles in the treatment of osteoporosis: a review.

IF 12.5 2区 医学 Q1 SURGERY
Zixiang Geng, Tiancheng Sun, Long Yuan, Yongfang Zhao
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引用次数: 0

Abstract

Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass, microstructural deterioration, and increased fracture risk. The crucial role of extracellular vesicles (EVs) in the occurrence and development of osteoporosis has garnered attention, with vesicle-based treatments showing significant promise. Compared to conventional osteoporosis medications, EVs possess characteristics of naturalness, selectivity, and adaptability, and more importantly, they have negligible side effects. Hence, this review discusses the applications of natural and engineered EVs in osteoporosis are comprehensively outlined. Unfortunately, the absence of consensus on the extraction, purification, characterization, and storage of EVs has resulted in a lack of clinical evidence supporting their application in patients with osteoporosis. Although significant progress is still needed before the clinical use of EVs can be achieved, their substantial potential remains undeniable. Moreover, considering the complexity of bone metabolism in osteoporosis and the heterogeneity of EVs, further investigation into the functional subpopulations of different exosomes will facilitate their application.

细胞外囊泡治疗骨质疏松症的现有证据综述。
骨质疏松症是一种全身性代谢性骨病,其特征是骨量减少、显微结构恶化和骨折风险增加。细胞外囊泡(EVs)在骨质疏松症的发生和发展中的关键作用已经引起了人们的关注,基于囊泡的治疗显示出显著的前景。与传统的骨质疏松药物相比,ev具有天然、选择性、适应性等特点,更重要的是其副作用可以忽略不计。因此,本文综述了天然细胞外囊泡和工程细胞外囊泡在骨质疏松症中的应用。不幸的是,由于对ev的提取、纯化、表征和储存缺乏共识,导致缺乏支持其在骨质疏松症患者中的应用的临床证据。尽管在实现电动汽车的临床应用之前仍需要取得重大进展,但其巨大潜力仍然是不可否认的。此外,考虑到骨质疏松症中骨代谢的复杂性和EVs的异质性,进一步研究不同外泌体的功能亚群将有助于其应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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