Comparison of two-year clinical and patient-reported outcome measures between Acrysof IQ and Clareon PanOptix multifocal intraocular lenses.

IF 4.1 1区 医学 Q1 OPHTHALMOLOGY
Raimo Tuuminen, Sohee Jeon
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引用次数: 0

Abstract

Purpose: To compare the 2-year clinical and patient-reported outcome measures of PanOptix multifocal intraocular lenses (MIOLs) based on the lens material.

Design: Retrospective matched cohort study.

Subjects: One hundred twenty-two eyes of 122 patients in each group.

Methods: A comparison between bilaterally operated patients with Acrysof IQ versus Clareon PanOptix MIOLs was done by one-to-one matching of age, axial length, mean keratometry, and corneal astigmatism.

Main outcome measures: The uncorrected near and distance visual acuities (UNVA and UDVA), prediction error in spherical equivalent and postoperative refraction stability, glistening, sub-surface nano-glistening (SSNG), Nd:YAG laser posterior capsulotomy rates, the area under the log contrast sensitivity function (AULCSF) under photopic and mesopic conditions, Strehl ratio and Area ratio were analyzed. Furthermore, patient-reported outcome measures such as dysphotopsia and modified spectacle-independent Visual Function Index (VF)-14 questionnaire scores were collected at 2 years.

Results: Throughout the study period, comparable UNVA, UDVA, and refractive stability were observed between the groups, except for better UNVA among eyes with Clareon than Acrysof IQ at 2 years (0.00±0.02 vs. 0.02±0.04, P<0.001). Clareon implantation resulted in better photopic (1.47±0.19 vs. 1.38±0.21 logCWeber units; P<0.001), and mesopic (1.16±0.22 vs. 1.06±0.19 logCWeber units; P<0.001) AULCSF, lower prevalence of glistening (0% vs. 88%, P<0.001) and SSNG (0% vs. 26%, P<0.001) and cumulative Nd:YAG laser capsulotomy rates (HR 0.632; 95%CI 0.482-0.830, P<0.001) when compared to those with Acrysof IQ. No differences were observed in the incidence of clinically significant glare or halos, but the incidence of starburst (5% vs. 16%, P=0.002) tended to favor Clareon over Acrysof IQ. Modified VF-14 questionnaire scores were greater for Clareon than Acrysof IQ (93.4±10.3 vs. 90.4±13.6 points, P<0.001). A multivariable regression analysis showed that the patient's age (beta=-0.394, P<0.001; beta=-0.352, P<0.001) and glistening grade (beta=-0.163, P=0.010; beta=-0.232, P<0.001) remained significantly associated with the photopic and mesopic AULCSF, respectively. Furthermore, higher glistening grade (r=-0.144, P=0.003; beta=-1.771, P=0.001 when age and sex-adjusted) associated with worse modified VF-14 questionnaire scores.

Conclusions: Clareon PanOptix outperformed Acrysof IQ PanOptix in visual quality and spectacle-independent visual function, potentially resulting from a lower prevalence of glistening.

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来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
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