Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of separation science Pub Date : 2025-03-16 DOI:10.1002/jssc.70122

Meihong Chai, Chang Liu, Liping Zhang, Yi Wang, Xueyan Zhen, Yi Yang, Yanping Huang, Zhaosheng Liu

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引用次数: 0

Abstract

A novel molecularly imprinted polymer (MIP) against gatifloxacin based on a hybrid monomer (3-triethoxysilylpropyl methacrylic amide, APTES-MAA) was reported. In this study, the imprinted monolith was synthesized with gatifloxacin as template, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and APTES-MAA as functional monomer in a mixture of acetonitrile and isooctane as porogen via an optimization based on density functional theory (DFT). The polymers were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and mercury porosimetry. The resulting hybrid MIPs (HMIPs) showed high affinity and selectivity to the template molecule with an imprinted factor of 16.28 ± 0.53, which was 6.1 times higher than that of the traditional methacrylic acid–based MIP. The MIP was used as an adsorbent in solid-phase extraction of lake water with gatifloxacin. The recovery was 96.52 ± 2.69%. The method exhibits the advantageous features of cost-effectiveness and high sensitivity, rendering it a promising approach for analyzing organic pollutants in water.

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.