Progress in trifluoromethylation reaction of olefins

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-05 DOI:10.1016/j.tet.2025.134545

Li-Jun Li, Xin-Yue Li, Jin Zhang, Hong Li, Qiang-Wei Fan, Yang Li

引用次数: 0

Abstract

The presence of trifluoromethyl in the drug molecule can effectively improve its lipophilicity, absorbability, and metabolic stability. Therefore, the introduction of trifluoromethyl in organic molecules has attracted widespread attention. In recent years, the trifluoromethylation of olefins has been developed rapidly. In this paper, various synthesis methods and reaction mechanisms of trifluoromethylated olefins in recent years are reviewed from the perspectives of transition metal (Cu, Fe, Pd, Ni) catalysis and photocatalysis and free radical reactions.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.