Unveiling the diversity and potential of STR markers across India - a systematic review

IF 0.5 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2025-03-14 DOI:10.1016/j.humgen.2025.201400

Soupayan Banerjee , Tanurup Das , Gyaneshwer Chaubey , Ankit Srivastava

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Abstract

This systematic review explores the genetic diversity and potential of Short Tandem Repeat (STR) markers across India. STR markers, characterized by variations in the number of repeated DNA sequences among individuals, are highly informative for distinguishing between individuals and populations. This review synthesizes findings from studies conducted across various Indian states, highlighting unique genetic profiles and population structures. The analysis underscores the importance of incorporating regional genetic data in genetic studies and emphasizes the need for further research to elucidate the complex genetic landscape, which can, in turn, support the development of an indigenous STR marker list specific to India. Several indigenous genetic markers, not included in widely used global databases, have proven to be highly informative in the Indian population. These markers offer valuable insights into genetic diversity and population structure, aiding forensic applications such as individual identification and kinship analysis.

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揭示印度STR标记的多样性和潜力——一项系统综述

本系统综述探讨了印度短串联重复序列（STR）标记的遗传多样性和潜力。STR标记以个体之间重复DNA序列的数量变化为特征，对个体和群体之间的区分具有很高的信息性。这篇综述综合了在印度各个邦进行的研究结果，突出了独特的遗传图谱和人口结构。该分析强调了将区域遗传数据纳入遗传研究的重要性，并强调需要进一步研究以阐明复杂的遗传景观，这反过来可以支持开发印度特有的STR标记清单。一些未被广泛使用的全球数据库收录的土著遗传标记已被证明在印度人口中具有很高的信息性。这些标记为遗传多样性和种群结构提供了有价值的见解，有助于个体鉴定和亲属关系分析等法医应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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