Multidrug-resistant Serratia marcescens: A growing threat in Iraqi intensive care units

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-03-13 DOI:10.1016/j.genrep.2025.102197

Israa M.S. AL-Kadmy , Nadal A. Al-Saryi , Istabreq Muhammed Ali Salman , Eman Thamer Garallah , Sarah Naji Aziz , Sawsan Sajid Al-Jubori , Eman Natiq Naji , Eman Alhomaidi , Salam S. Alsharari , Yasmin N. Ramadan , Helal F. Hetta

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引用次数: 0

Abstract

Background and aim

Serratia marcescens (S. marcescens) poses a growing threat to ICU patients, particularly due to its multidrug resistance (MDR). This study evaluates the prevalence of antimicrobial resistance and associated genes in ICU isolates in Baghdad, highlighting clinical implications.

Methodology

A total of 101 isolates were analyzed using biochemical and molecular techniques. Antibiotic susceptibility and resistance gene profiles were assessed via standardized testing and PCR.

Results

Among 101 S. marcescens isolates, 71 were MDR. Universal resistance to beta-lactams was noted, with key genes (blaCTX-M and blaSHV) detected in all isolates, while blaCMY and blaTEM were present in approximately 95 % and 89 % of isolates. Additionally, carbapenemase genes were detected in up to 90 % of isolates, underscoring a significant resistance burden.

Conclusion

The study highlights the critical threat posed by multidrug-resistant S. marcescens in ICU settings, emphasizing the need for improved infection control and therapeutic innovation.

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耐多药粘质沙雷菌：伊拉克重症监护病房日益严重的威胁

背景与目的粘质沙雷氏菌（S. marcescens）对ICU患者的威胁越来越大，特别是由于其耐多药（MDR）。本研究评估了巴格达ICU分离株抗微生物药物耐药性和相关基因的流行情况，强调了临床意义。方法采用生化和分子技术对101株分离物进行分析。通过标准化检测和PCR评估抗生素敏感性和耐药基因谱。结果101株粘质葡萄球菌中71株为耐多药。所有分离株均检测到关键基因（blaCTX-M和blaSHV），而blaCMY和blaTEM分别存在于约95%和89%的分离株中。此外，在高达90%的分离株中检测到碳青霉烯酶基因，强调了显著的耐药负担。结论本研究强调了耐多药粘质葡萄球菌对ICU环境的严重威胁，强调了改善感染控制和创新治疗方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.