EEG microstates during resting-state and dissociative events in patients with psychogenic non-epileptic seizures

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-03-08 DOI:10.1016/j.clinph.2025.03.002

Cecilia Catania , Marco Mancuso , Adolfo Mazzeo , Enrico Michele Salamone , Biagio Orlando , Alessandra Morano , Giorgio Leodori , Sara Casciato , Giancarlo Di Gennaro , Anna Teresa Giallonardo , Carlo Di Bonaventura , Emanuele Cerulli Irelli

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引用次数: 0

Abstract

Objective

Previous neuroimaging studies indicate complex network alterations in psychogenic non-epileptic seizures (PNES) patients, but brain activity modifications occurring during PNES remain unexplored. This study aimed to analyze EEG microstate metrics in PNES patients both during events and resting state to investigate the neurophysiological changes underlying these dissociative events.

Methods

We recruited 22 PNES patients and 24 age- and sex-matched healthy controls. Inclusion criteria included a history of PNES and at least one recorded akinetic PNES during video-EEG.

Results

A two-way repeated-measures ANOVA revealed significant class*condition interactions for microstate duration (p = 0.017), coverage (p = 0.012), and global field power (GFP) (p = 0.008). Post-hoc FDR-adjusted paired t-tests showed a significant decrease in microstate C duration (p = 0.036), coverage (p = 0.04), and GFP (p = 0.036) during PNES events compared to resting state. Mann-Whitney U tests showed significantly higher microstate C duration in PNES patients during resting state compared to controls (p = 0.009).

Conclusions

Microstate C, previously associated with the default mode network, showed increased duration during resting state and decreased representation during PNES, suggesting a prominent shift in neural activity dynamics within this network during dissociative events.

Significance

These findings provide insights into neurophysiological changes occurring during PNES, suggesting an interplay between pathological and adaptive mechanisms in their pathophysiology.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.