Early peripheral nerve impairments in type 1 diabetes are associated with cortical inhibition of ankle joint proprioceptive afference

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-03-10 DOI:10.1016/j.clinph.2025.02.277

Toni Mujunen , Urho Sompa , Miguel Muñoz-Ruiz , Elina Monto , Valtteri Rissanen , Heli Ruuskanen , Petteri Ahtiainen , Harri Piitulainen

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引用次数: 0

Abstract

Objective

Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of type 1 diabetes mellitus (T1DM). However, it is still unclear how the cortical processing of proprioceptive afference is altered due to DSPN.

Methods

Cortical responses to right and left ankle joint rotations were recorded with magnetoencephalography and pooled together in 20 T1DM participants and 20 healthy controls for source space comparisons. T1DM participants also underwent a lower limb nerve–conduction study to correlate peripheral nerve function with the cortical responses.

Results

Primary sensorimotor (SM1) cortex activation was wider in T1DM patients during beta suppression, with no between–group differences in the response strength. However, stronger beta suppressions in T1DM patients were correlated with axon–loss in the peripheral sensory afferents (p < 0.05). Weaker beta rebounds and stronger SM1 evoked field amplitudes were associated with impaired conduction velocities in the mixed nerves (p < 0.05). Lastly, stronger SM1 beta power was associated with both demyelination and axon–loss in the lower limb sensory afferents (p < 0.05).

Conclusions

T1DM is accompanied with wider SM1 cortex activation to proprioceptive stimuli, and the early asymptomatic DSPN impairments are linked to increased levels of cortical inhibition.

Significance

T1DM is associated with comprehensive central pathophysiology evident in early DSPN.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.