Lin Liang , Yu Wang , Haoran Chen , Jianrong Huo , Shilong Yu , Junxing Zhao
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引用次数: 0
Abstract
Sea buckthorn (SB) berries, which are non-toxic, contain diverse bioactive substances with high nutritional value and beneficial medicinal properties. This study aims to explore the effects of maternal dietary SB during pregnancy and lactation on high-fat diet (HFD) induced obesity in offspring. The results showed that maternal SB intake reduced offspring body weight and fat mass, and improved both glucose tolerance and insulin sensitivity. Furthermore, offspring of dams fed SB exhibited lower expression of inflammatory response factors, such as IL-6, IL-10, and TNF-α, and higher energy metabolism in BAT to resist the cold environment than the descendants of only HFD-fed dams. Meanwhile, markers for BAT were dramatically upregulated in offspring of HFDSB-fed dams. Finally, dietary SB restored the number of functional mitochondria by increasing PKM2 and FASN expression. Taken together, this study reveals a novel approach for alleviating offspring obesity induced by HFD in terms of maternal SB supplementation.
期刊介绍:
Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies.
The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients.
The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.