Feeling at home in a virtually amputated body; neural and phenomenological effects of illusory embodiment in body integrity dysphoria

IF 3.7 2区 医学 Q1 PSYCHIATRY
Gianluca Saetta , Yannik Peter , Kathy Ruddy , Jasmine T. Ho , Roger Luechinger , Emily Cross , Lars Michels , Bigna Lenggenhager
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Abstract

In Body Integrity Dysphoria (BID) a profound incongruity between the physical body and the desired, i.e., amputated body, often leads to a desire for limb amputation. Virtual reality (VR) and multisensory stimulation paradigms provide powerful tools to create the experience of being embodied in an amputated body.
Here we investigate the impact of such an experience on neural and subjective responses in 18 individuals with BID and 18 controls. We used both task-based and resting-state MRI before and after participants played an immersive virtual game in an amputated body corresponding to their desired bodily shape and mimicking their movements. The task-based fMRI assessed neural activity when viewing images of the body in the desired versus the undesired state.
Individuals with BID reported higher sense of ownership and control over the virtual body. Task-based fMRI showed increased pre-VR activity in the right superior parietal lobule (rSPL), right angular gyrus, and right supplementary motor area in the BID group, normalizing after VR exposure. Resting-state fMRI showed reduced connectivity in the rSPL, visuo-occipital areas, fronto-parietal, and fronto-striatal mirror and limb system networks, also normalizing post-VR. Additionally, there was a normalization in the pattern of increased connectivity of cortico-striatal tracts connecting the rSPL and the pars orbitalis of the right inferior frontal gyrus with the nucleus accumbens.
Our findings suggest that virtual embodiment effectively modulates BID-related neural networks, offering a safe, cost-effective intervention for BID and highlights VR's potential in exploring the complex interaction between body and self, with potential implications for similar psychiatric conditions.
在一个几乎被截肢的身体里感到自在;虚幻化身在身体完整性焦虑症中的神经和现象学效应
在身体完整不安症(BID)中,身体与被截肢的身体之间的严重不协调通常会导致截肢的愿望。虚拟现实(VR)和多感官刺激范式提供了强大的工具来创造被截肢身体具体化的体验。在这里,我们研究了这种经历对18名BID患者和18名对照组的神经和主观反应的影响。我们在参与者玩一个与他们想要的身体形状相对应的截肢身体的沉浸式虚拟游戏并模仿他们的动作之前和之后使用了基于任务和静息状态的MRI。以任务为基础的功能磁共振成像(fMRI)评估了在观看理想状态和不理想状态下的身体图像时的神经活动。患有BID的人对虚拟身体有更高的所有权和控制感。任务型fMRI显示,在VR前,BID组的右侧顶叶上叶(rSPL)、右侧角回和右侧辅助运动区活动增加,在VR暴露后恢复正常。静息状态fMRI显示rSPL、视枕区、额顶叶、额纹状体镜像和肢体系统网络的连通性降低,vr后也正常化。此外,连接rSPL和右侧额下回眶部的皮质纹状体束与伏隔核的连通性增加的模式也趋于正常化。我们的研究结果表明,虚拟化身有效地调节了与BID相关的神经网络,为BID提供了一种安全、经济的干预措施,并突出了VR在探索身体与自我之间复杂相互作用方面的潜力,对类似精神疾病有潜在的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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