Boosting cuproptosis by activating JAK-STAT signaling pathway and synergrtic with interface-enhanced sonodynamic immunotherapy against cancer

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today Pub Date : 2025-03-15 DOI:10.1016/j.nantod.2025.102701

Changhong Zhao , Xinshu Zhu , Huili Yang , Fei Kong , Yuxin Yang , Ruohan Gong , Yuqiong Yang , Qinglu Luo , Ruike Zhang , Jieni Fu , Zhenhong Su , Yuan Li , Hongbo Wu

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引用次数: 0

Abstract

The poor immunogenicity of most tumors caused low eﬃcacy of immunotherapy underlines the importance of activating immune system and provoking immunogenic apoptosis to enhance the treatment efficiency of immunotherapy. Here, the heterojunction was designed against breast cancer through eliciting localized sonodynamic therapy and activating cuproptosis-mediated immunotherapy. The enhanced piezocatalysis effect of Cu₂O/vanadium carbide/curcumin (Cu₂O/V₂C/Cur) mainly originated from the formation of dual interfacial electric field in the heterojunction of Cu₂O/V₂C under ultrasound irradiation, which can efficiently improve the separation efficiency of electron-hole pairs, inhibit their compounding efficiency, thus enhance the sonodynamic activity. During the process, the apoptosis caused by cuproptosis was also enhanced by down-regulating the expression of downstream cuproptosis-related genes and enhancing the over-accumulation of Cu^2 + in mitochondrial respiration-dependent cells through activating JAK-STAT signaling pathway in 4T1 cells. Meanwhile, Cu₂O/V₂C/Cur also activated immune response by modulating the proportion of CD8⁺ T cells, which synergizes with sonodynamic-enhanced cuproptosis to efficiently treat breast cancer. Thus, this investigation put up with a feasible method for enhancing the treatment efficiency of immunotherapy by designing a sonodynamic-enhanced cuproptosis strategy.

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.