The impact of bright light therapy on Parkinson's disease: A pilot study using vestibular-evoked myogenic potentials

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-03-10 DOI:10.1016/j.parkreldis.2025.107776

Wei-ye Xie , Wen-xiang Duan , Ying Chen , Meng-xing Tao , Han-xing Li , Fan Gao , Jie-yun Yin , Jia-hui Yan , Fen Wang , Cheng-jie Mao , Yun Shen , Chun-feng Liu

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引用次数: 0

Abstract

Introduction

Bright light therapy (BLT) has been proved to have beneficial effects on Parkinson's disease (PD). Brainstem pathways improvements might be crucial to BLT, but the mechanisms remained unclear. The aim of this study is to validate whether BLT improves clinical symptoms in PD and thus explore the possible mechanisms of brainstem pathways evaluated by vestibular-evoked myogenic potentials (VEMPs).

Methods

A total of 22 PD patients participated were enrolled in this crossover randomized placebo-controlled study. Participants received either one month of BLT or dim light therapy (DLT), separated by a 1-month wash-out period, and underwent clinical scales and VEMPs evaluations before and after each intervention. Mixed-effects regression models were used to determine the effect between BLT and DLT on PD patients by the differentials of clinical scales (Δscales) and VEMPs (ΔVEMPs). Correlations between the improvement of clinical symptoms and VEMPs parameters improvements were analyzed in PD patients receiving BLT.

Results

Excessive daytime sleepiness, anxiety, life quality and autonomic function were improved after BLT. Compared to DLT, the difference was not significant. There were significant differences of cervical VEMPs (cVEMP) and ocular VEMPs (oVEMP) peak latencies after BLT. Compared with DLT, there was significant difference in ΔLp13, ΔRp13 and ΔLp11 peak latencies after BLT.

Conclusions

BLT may be a valuable non-pharmacological intervention for improving brainstem function, thereby enhancing quality of life and overall health in PD patients.

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强光疗法对帕金森病的影响：使用前庭诱发肌源性电位的试点研究

导言亮光疗法（BLT）已被证明对帕金森病（PD）有益处。脑干通路的改善可能是亮光疗法的关键，但其机制仍不清楚。本研究旨在验证 BLT 是否能改善帕金森病的临床症状，从而探索通过前庭诱发肌源性电位（VEMPs）评估脑干通路的可能机制。参加者接受了为期一个月的BLT或暗光疗法（DLT），中间有一个月的冲淡期，并在每次干预前后接受了临床量表和VEMPs评估。混合效应回归模型通过临床量表（Δscales）和VEMPs（ΔVEMPs）的差异来确定BLT和DLT对PD患者的影响。结果接受BLT治疗后，白天过度嗜睡、焦虑、生活质量和自主神经功能均得到改善。与DLT相比，差异不显著。BLT后，颈部VEMPs（cVEMP）和眼部VEMPs（oVEMP）峰值潜伏期有明显差异。与DLT相比，BLT后ΔLp13、ΔRp13和ΔLp11峰值潜伏期有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.