Curcumin delivery system based on a chitosan-liposome encapsulated zeolitic imidazolate framework-8: a potential treatment antioxidant and antibacterial treatment after phacoemulsification.

Biomedical materials (Bristol, England) Pub Date : 2025-04-03 DOI:10.1088/1748-605X/adc05c

Meiting Lin, Kunyuan Tang, Wendi Zheng, Shijie Zheng, Ke Hu

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Abstract

Curcumin is a natural polyphenol extracted from plants that can interact with various molecular targets, including antioxidant, antibacterial, anticancer, and anti-aging activities. Due to its variety of pharmacological activities and large margin pf safety, curcumin has been used in the prevention and treatment of various diseases, such as Alzheimer's, heart, and rheumatic immune diseases. To develop curcumin eye drops that can be used as antioxidant and antibacterial agents after phacoemulsification, we have designed a nano-based drug delivery system to improve curcumin bioavailability and duration of action. We successfully prepared zeolitic imidazolate framework-8 (ZIF-8) coated with chitosan-liposome (Cur@ZIF-8/CS-Lip) for curcumin delivery. It can release curcumin for over 20 hin vitroand exhibits excellent biosafety, antioxidant, and antibacterial activities. Therefore, we hypothesized that Cur@ZIF-8/CS-Lip could reduce the incidence of oxidative stress and infection after cataract surgery.

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基于壳聚糖-脂质体包裹沸石咪唑酸框架-8的姜黄素输送系统：一种潜在的乳化术后抗氧化和抗菌治疗方法。

姜黄素是一种从植物中提取的天然多酚，它与各种分子靶点相互作用，具有抗氧化、抗菌、抗癌和抗衰老的特性。由于姜黄素具有多种药理活性和较高的安全边际，已被用于预防和治疗多种疾病，包括阿尔茨海默病、心脏病和风湿性免疫疾病。为了研制可作为超声乳化术后抗氧化和抗菌药物的姜黄素滴眼液，我们设计了一种纳米给药系统，以提高姜黄素的生物利用度和作用时间。我们成功制备了壳聚糖脂质体包裹的咪唑酸分子筛框架-8 (ZIF-8)，用于姜黄素的递送（Cur@ZIF-8/CS-Lip）。该系统可使姜黄素在体外持续释放超过20小时，并具有良好的生物安全性、抗氧化和抗菌活性。因此，我们提出Cur@ZIF-8/CS-Lip可能降低白内障手术后氧化应激和感染的发生率。。

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Biomedical materials (Bristol, England)

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