HID-CON: weakly supervised intrahepatic cholangiocarcinoma subtype classification of whole slide images using contrastive hidden class detection.

IF 1.9 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal of Medical Imaging Pub Date : 2025-11-01 Epub Date: 2025-03-12 DOI:10.1117/1.JMI.12.6.061402
Jing Wei Tan, Kyoungbun Lee, Won-Ki Jeong
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引用次数: 0

Abstract

Purpose: Biliary tract cancer, also known as intrahepatic cholangiocarcinoma (IHCC), is a rare disease that shows no clear symptoms during its early stage, but its prognosis depends highly on the cancer subtype. Hence, an accurate cancer subtype classification model is necessary to provide better treatment plans to patients and to reduce mortality. However, annotating histopathology images at the pixel or patch level is time-consuming and labor-intensive for giga-pixel whole slide images. To address this problem, we propose a weakly supervised method for classifying IHCC subtypes using only image-level labels.

Approach: The core idea of the proposed method is to detect regions (i.e., subimages or patches) commonly included in all subtypes, which we name the "hidden class," and to remove them via iterative application of contrastive loss and label smoothing. Doing so will enable us to obtain only patches that faithfully represent each subtype, which are then used to train the image-level classification model by multiple instance learning (MIL).

Results: Our method outperforms the state-of-the-art weakly supervised learning methods ABMIL, TransMIL, and DTFD-MIL by 17 % , 18%, and 8%, respectively, and achieves performance comparable to that of supervised methods.

Conclusions: The introduction of a hidden class to represent patches commonly found across all subtypes enhances the accuracy of IHCC classification and addresses the weak labeling problem in histopathology images.

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来源期刊
Journal of Medical Imaging
Journal of Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.10
自引率
4.20%
发文量
0
期刊介绍: JMI covers fundamental and translational research, as well as applications, focused on medical imaging, which continue to yield physical and biomedical advancements in the early detection, diagnostics, and therapy of disease as well as in the understanding of normal. The scope of JMI includes: Imaging physics, Tomographic reconstruction algorithms (such as those in CT and MRI), Image processing and deep learning, Computer-aided diagnosis and quantitative image analysis, Visualization and modeling, Picture archiving and communications systems (PACS), Image perception and observer performance, Technology assessment, Ultrasonic imaging, Image-guided procedures, Digital pathology, Biomedical applications of biomedical imaging. JMI allows for the peer-reviewed communication and archiving of scientific developments, translational and clinical applications, reviews, and recommendations for the field.
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