The long-term impact of single intraoperative instillation of pirarubicin after radical nephroureterectomy on local and systemic cancer control: a prospective, multicenter, randomized trial.

IF 2.8 2区 医学 Q2 UROLOGY & NEPHROLOGY
Toru Suzuki, Akihiro Kanematsu, Shiro Tanaka, Sojun Kanamaru, Toshinari Yamasaki, Mutsushi Kawakita, Shingo Yamamoto
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引用次数: 0

Abstract

Purpose: Although the preventive effect against intravesical recurrence (IVR) has been established for single instillation of chemotherapy during or after radical surgery of upper urinary tract urothelial carcinoma (UTUC), there has been no research on the long-term outcome. This study aims to investigate the IVR and long-term survival outcome of a single intraoperative instillation of pirarubicin during radical nephroureterectomy (RNU).

Methods: In this prospective, multicenter, randomized trial, 97 patients undergoing RNU between August 2012 and January 2019 were randomly assigned either to receive a single intraoperative pirarubicin instillation or to serve as the controls.

Results: A total of 80 patients were analyzed, including 42 in the pirarubicin group and 38 in the control group. The median follow-up period was 58.5 months and 62 months in the pirarubicin and the control groups, respectively. In patients who did not experience IVR, the median follow-up period was 59 months and 61 months in the pirarubicin and the control groups, respectively. There was no significant difference in OS between the two groups, although the IVR rate was significantly lower in pirarubicin group (p = 0.044). Multivariable analyses revealed that the pirarubicin instillation was the only independent factor for IVR.

Conclusions: The present trial demonstrated that a single intraoperative instillation of pirarubicin resulted in a significant and long-term reduction of IVR, although there was no significant difference in OS.

根治性肾输尿管切除术后术中单次滴注吡柔比星对局部和全身癌症控制的长期影响:一项前瞻性、多中心、随机试验
目的:虽然上尿路尿路上皮癌(UTUC)根治术中或术后单次滴注化疗对膀胱内复发(IVR)有预防作用,但对其远期疗效尚无研究。本研究旨在探讨根治性肾输尿管切除术(RNU)中单次术中灌注吡柔比星的IVR和长期生存结果。方法:在这项前瞻性、多中心、随机试验中,2012年8月至2019年1月期间接受RNU的97例患者被随机分配为术中单次滴注吡柔比星或作为对照组。结果:共分析80例患者,其中吡柔比星组42例,对照组38例。吡柔比星组和对照组的中位随访时间分别为58.5个月和62个月。在未经历IVR的患者中,吡柔比星组和对照组的中位随访期分别为59个月和61个月。两组间OS差异无统计学意义(p = 0.044),吡柔比星组IVR率明显低于两组(p = 0.044)。多变量分析显示吡柔比星滴注是IVR的唯一独立因素。结论:本试验表明,术中单次滴注吡柔比星可显著降低IVR,但OS无显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World Journal of Urology
World Journal of Urology 医学-泌尿学与肾脏学
CiteScore
6.80
自引率
8.80%
发文量
317
审稿时长
4-8 weeks
期刊介绍: The WORLD JOURNAL OF UROLOGY conveys regularly the essential results of urological research and their practical and clinical relevance to a broad audience of urologists in research and clinical practice. In order to guarantee a balanced program, articles are published to reflect the developments in all fields of urology on an internationally advanced level. Each issue treats a main topic in review articles of invited international experts. Free papers are unrelated articles to the main topic.
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