Preparations for Ultra-High Dose Rate 25-90 MeV Electron Radiation Experiments with a Compact, High-Peak-Current, X-band Linear Accelerator.

IF 2.5 3区 医学 Q2 BIOLOGY
Haytham H Effarah, Trevor Reutershan, Michael W L Seggebruch, Martin Algots, Alexander Amador, Janet Baulch, Olivia G G Drayson, Frederic V Hartemann, Yoonwoo Hwang, Agnese Lagzda, Ferenc Raksi, Charles L Limoli, Christopher P J Barty
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引用次数: 0

Abstract

The Distributed Charge Compton Source (DCCS) developed by Lumitron Technologies, Inc. has produced a 25-MeV electron beam with 1.7-nC macrobunches at a 100-Hz repetition rate from a compact, high-gradient X-band (11.424 GHz) accelerator. The DCCS is currently being commissioned to produce 100-MeV-class electrons, well within the very high energy electron (VHEE) energy regime, with macrobunch charges of up to 25 nC at repetition rates up to 400 Hz. The DCCS is also designed to produce imaging X rays through Laser Compton scattering. This work aims to describe the preparations for the first dosimetry experimental campaign using this accelerator system at energies ranging from 25 MeV to 90 MeV through hardware development and Monte Carlo (TOPAS) simulation studies. A significant goal of these preparations is to configure the machine so that it can be used to both image with X rays and subsequently treat with VHEEs without movement of the animal model under study. At ultra-high dose rates, this X-ray image-guided electron source could be used to investigate dose-rate dependent differential sparing of normal and malignant biological tissue, known as the FLASH effect. An indium-tin-oxide-coated, 100-μm-thick diamond window was obtained and installed in a custom flange assembly to act as the electron/X-ray vacuum exit window. Simulations at 25 MeV suggest that a scattering foil and collimator can shape the output of the accelerator to produce a 12-mm-diameter, flat-field, circular beam with a 1.7-nC macrobunch charge. This corresponds to an entrance dose of 10 Gy in less than 100 ms. These initial results highly motivate an experimental campaign toward investigating VHEE FLASH using the DCCS at Lumitron Technologies, Inc.

25- 90mev超高剂量率电子辐射实验用小型峰值电流x波段直线加速器的制备
由Lumitron Technologies, Inc.开发的分布式电荷康普顿源(DCCS)已经从紧凑的高梯度x波段(11.424 GHz)加速器中产生了25 mev的1.7 nc巨束,100 hz重复率的电子束。DCCS目前正被委托生产100 mev级的电子,在非常高能电子(VHEE)能量范围内,以高达400 Hz的重复率产生高达25 nC的大束电荷。DCCS还设计用于通过激光康普顿散射产生成像X射线。本工作旨在通过硬件开发和蒙特卡罗(TOPAS)模拟研究,描述使用该加速器系统在25 MeV至90 MeV能量范围内进行首次剂量学实验活动的准备工作。这些准备工作的一个重要目标是配置机器,使其既可以用X射线成像,又可以在不移动所研究的动物模型的情况下使用VHEEs治疗。在超高剂量率下,这种x射线图像引导电子源可用于研究正常和恶性生物组织的剂量率依赖性差异保留,称为FLASH效应。制备了一个100 μm厚的氧化铟锡涂层金刚石窗口,并将其安装在定制的法兰组件中,作为电子/ x射线真空出口窗口。在25 MeV下的模拟表明,散射箔片和准直器可以塑造加速器的输出,产生直径12毫米的平场圆形光束,具有1.7 nc的大束电荷。这相当于在不到100毫秒的时间内接受10戈瑞的入射剂量。这些初步结果极大地激发了Lumitron科技公司利用DCCS研究VHEE FLASH的实验活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiation research
Radiation research 医学-核医学
CiteScore
5.10
自引率
8.80%
发文量
179
审稿时长
1 months
期刊介绍: Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.
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