Solubilisation of quercetin in phospholipid complex improves its anti-hyperuricaemia activity in mice.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-03-14 DOI:10.1080/14786419.2025.2478647

Liping Ju, Jiale Mao, Lingling Wang, Jing Wang, Lu Zhao, Caihong Shi, Xu Zhao

{"title":"Solubilisation of quercetin in phospholipid complex improves its anti-hyperuricaemia activity in mice.","authors":"Liping Ju, Jiale Mao, Lingling Wang, Jing Wang, Lu Zhao, Caihong Shi, Xu Zhao","doi":"10.1080/14786419.2025.2478647","DOIUrl":null,"url":null,"abstract":"<p><p>Previous studies have confirmed that quercetin (Que) has a good therapeutic effect on lowering uric acid and hyperuricaemia. However, due to its poor water solubility, the bioavailability is low with limited application. This research aimed to prepare quercetin phospholipid complex (Que-PC) to improve the solubility, and the physicochemical properties and anti-hyperuricaemia activity of Que-PC were investigated. Que-PC was prepared by solvent evaporation and characterised by FTIR, SEM and XRD as an amorphous structure. Compared with Que, the solubility of Que-PC in water and n-octanol increased by 179.3 times and 440.6 times, respectively. The results of biochemical indicators including serum uric acid, creatinine, urea nitrogen, and xanthine oxidase levels, and renal tissue status indicated that Que-PC significantly enhanced the uric acid lowering activity and renal protective effect of Que. These results contribute to the development of insoluble compound drug delivery systems and provide a basis for further research on quercetin-related drugs.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2478647","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Previous studies have confirmed that quercetin (Que) has a good therapeutic effect on lowering uric acid and hyperuricaemia. However, due to its poor water solubility, the bioavailability is low with limited application. This research aimed to prepare quercetin phospholipid complex (Que-PC) to improve the solubility, and the physicochemical properties and anti-hyperuricaemia activity of Que-PC were investigated. Que-PC was prepared by solvent evaporation and characterised by FTIR, SEM and XRD as an amorphous structure. Compared with Que, the solubility of Que-PC in water and n-octanol increased by 179.3 times and 440.6 times, respectively. The results of biochemical indicators including serum uric acid, creatinine, urea nitrogen, and xanthine oxidase levels, and renal tissue status indicated that Que-PC significantly enhanced the uric acid lowering activity and renal protective effect of Que. These results contribute to the development of insoluble compound drug delivery systems and provide a basis for further research on quercetin-related drugs.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.