Sesquiterpenoid isolated from Colletotrichum truncatum derived from Gynura japonica: isolation, structure elucidation, and biological activity.

IF 1.9 3区 化学 Q3 CHEMISTRY, APPLIED
Riga Riga, Wandi Oktria, Ahadul Putra, Suryelita Suryelita, Adnan Luthfi Agusta, Okta Suryani, Sri Benti Etika, Bali Yana Fitri, Melindra Mulia, Edi Nasra, Desy Kurniawati, Khairil Arif, Dewi Meliati Agustini
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引用次数: 0

Abstract

The aim of this research was isolation, structure elucidation, and biological activities of terpenoids from endophytic fungus obtained from G. japonica. An endophytic fungus, Colletotrichum truncatum, was isolated from the roots of G. japonica. C. truncatum was cultivated and extracted to give the crude extract. The crude extract was fractionated using vacuum liquid chromatography followed by separation and purification with column chromatography to obtain a terpenoid derivative (12.8 mg). The compound was characterised for its structure using FT-IR and NMR spectra. Based on spectral analysis, the isolated compound was identified as sydonic acid. The isolated sydonic acid was active against three tested bacterial strains and also demonstrated antioxidant activity with an IC50 value of 76.5 ± 0.93 μg/mL. Interestingly, chemical research on the terpenoid derivative from the fungus C. truncatum associated with G. japonica is first reported herein.

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来源期刊
Natural Product Research
Natural Product Research 化学-医药化学
CiteScore
5.10
自引率
9.10%
发文量
605
审稿时长
2.1 months
期刊介绍: The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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