Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI:10.1177/03000605251325162

Ayed A Dera

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引用次数: 0

Abstract

ObjectiveThe study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients.MethodsThis cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy.ResultsMI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders (p < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy.ConclusionsElevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI.

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胰岛素抵抗型心肌梗死患者的循环瘦素和抵抗素水平。

目的研究胰岛素抵抗（HOMA-IR）的稳态模型评估与心肌梗死（MI）参数之间的联系，强调其作为沙特南部患者潜在的MI生物标志物的作用。这项横断面研究于2021年1月至4月在沙特阿拉伯阿巴哈的费萨尔·本·哈立德亲王心脏中心进行，研究了心肌梗死患者和对照组的心血管和糖尿病生物标志物，包括HOMA-IR，以评估胰岛素抵抗（IR）、风险和诊断准确性。结果与对照组相比，smi患者的HOMA-IR、瘦素、抵抗素、体重指数（BMI）和葡萄糖复合血红蛋白（HbA1c）水平均显著升高(p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605