Advances in Nanobiosensors for Rapid and Sensitive Detection of Dengue Virus Biomarkers by Using Clinical Laboratory.

Abstract

Background: The recent rise in dengue virus (DENV) cases poses a significant threat to human health, with infections ranging from mild to severe and potentially leading to premature death.

Objective: To highlight the importance of early detection of DENV and to review advancements in detection technologies, particularly focusing on nanobiosensors.

Methods: This review examines traditional detection methods for DENV, including molecular, serological, and direct virus culture techniques, while discussing their limitations. It also explores innovative technologies that enhance detection accuracy, speed, and efficiency.

Results: Nonstructural protein 1 (NS1) serves as a key biomarker present in high concentrations during the early stages of DENV infection, underscoring the need for timely detection. Traditional methods, while effective, have limitations that new technologies aim to address. Biosensors, particularly nanobiosensors, have emerged as promising tools for rapid, sensitive, and cost-effective DENV detection.

Conclusion: The adoption of advanced detection methods, especially nanobiosensors, is crucial for improving DENV management and reducing human suffering. This review provides a comprehensive overview of nanobiosensors and their applications, presented in an accessible manner for readers.