Corticoclaustral connections in the cat.

IF 0.6 4区 生物学 Q4 CELL BIOLOGY
B Landzhov, D Hinova-Palova, K Fakih, L Edelstein, L Gaydarski, A Alexandrov, V Kirkov, A Paloff, E Radeva
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Abstract

The claustrum is a sheet-like layer of gray matter situated between the external and extreme capsules of the mammalian brain. This structure was first described by the French physician and anatomist Vicq d'Azyr in 1786. The claustrum's phylogeny, ontogeny and functional characteristics have long been the subject of debate and considerable investigative efforts. However, despite such efforts (or perhaps as a result thereof), significant disparities and discrepancies remain, most notably in the context of the claustrum's afferent and efferent connections. For the purpose of this study, we sought to focus our efforts on fronto-claustral and occipito-claustral connections. Twelve healthy, adult male cats, each weighing ~ 3.5 kg, were studied, seven of which underwent electrolytic lesions of the frontal cortex (A3, A4, and a portion of A6), and five of the occipital cortex (A17, A18, A21). From three to six days after lesioning, subjects were euthanized in accordance with ethical norms. After the brains were removed and blocked, samples of the claustrum were taken and prepared for electron microscopy. Three to six days after lesions of the frontal cortex, we observed an abundance of degenerative boutons in the dorsal claustrum. The vast majority of boutons exhibited the characteristic signs of dark degeneration, whereas only 10% appeared to have undergone light degeneration. Similar results were seen in the dorsal claustrum over the same period of time following lesions of the visual cortex. These results suggest that the dorsal claustrum receives at least two types of connections - separately and concurrently - from the frontal and occipital cortices.

猫的皮质闭侧连接。
屏状体是一种片状的灰质层,位于哺乳动物大脑的外部和极端胶囊之间。1786年,法国内科医生和解剖学家Vicq d'Azyr首先描述了这种结构。屏蝽的系统发育、个体发育和功能特征长期以来一直是争论和大量研究工作的主题。然而,尽管有这样的努力(或者可能是其结果),显著的差异和差异仍然存在,最明显的是在屏状体的传入和传出连接的背景下。为了本研究的目的,我们试图将我们的努力集中在额-闭叶和枕-闭叶的连接上。研究了12只体重约3.5 kg的健康成年公猫,其中7只在额叶皮质(A3、A4和A6的一部分)和5只枕叶皮质(A17、A18、A21)进行了电解损伤。损伤后3 - 6天,按照伦理规范对受试者实施安乐死。在大脑被移除并阻塞后,取屏状体样本并准备用于电子显微镜。额叶皮质病变后3至6天,我们观察到背屏状体中有大量退行性钮扣。绝大多数钮扣表现出深色变性的特征,而只有10%的钮扣表现出浅色变性。在视觉皮层损伤后的同一时间内,在背屏状体中也观察到类似的结果。这些结果表明,背屏状体至少接受来自额叶和枕叶皮层的两种类型的连接——分别或同时进行。
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来源期刊
Journal of Histotechnology
Journal of Histotechnology 生物-细胞生物学
CiteScore
2.60
自引率
9.10%
发文量
30
审稿时长
>12 weeks
期刊介绍: The official journal of the National Society for Histotechnology, Journal of Histotechnology, aims to advance the understanding of complex biological systems and improve patient care by applying histotechniques to diagnose, prevent and treat diseases. Journal of Histotechnology is concerned with educating practitioners and researchers from diverse disciplines about the methods used to prepare tissues and cell types, from all species, for microscopic examination. This is especially relevant to Histotechnicians. Journal of Histotechnology welcomes research addressing new, improved, or traditional techniques for tissue and cell preparation. This includes review articles, original articles, technical notes, case studies, advances in technology, and letters to editors. Topics may include, but are not limited to, discussion of clinical, veterinary, and research histopathology.
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