The impact of thyroid function on surgical prognosis in patients undergoing cardiac and major vascular surgeries.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-03-14 DOI:10.1186/s13019-025-03365-2

Qi Sun, Wei Wang, Xiaoming Mao, Hao Liu

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引用次数: 0

Abstract

Objective: This study aims to elucidate the relationship between thyroid function and surgical prognosis in patients undergoing cardiac and major vascular surgeries.

Methods: A retrospective cohort study was conducted on patients undergoing cardiac or major vascular surgeries. Preoperative thyroid function tests, including TSH, free T3, and free T4 levels, as well as postoperative thyroid function tests, were assessed. Key postoperative outcomes, such as total hospital stay, postoperative hospital stay, ICU stay, and duration of mechanical ventilation, were recorded and analyzed. The analytical approach included Pearson correlation, multivariable logistic regression models, and restricted cubic splines.

Results: This study analyzed a cohort of 472 patients who underwent various cardiovascular surgeries, including coronary artery bypass grafting (173 patients), aortic surgery (131 patients), valve surgery (125 patients), and primary cardiac neoplasms resection (43 patients). Significant changes in thyroid hormone levels were observed preoperatively and postoperatively, with TSH, FT3, and FT4 levels showing a significant decrease from preoperative values (p < 0.001). Multivariate logistic regression analysis further revealed that ΔTSH is significantly associated with total hospital stay, postoperative hospital stay, and duration of mechanical ventilation; postoperative FT3 levels were significantly inversely related to total hospital stay, ICU stay, and ventilator requirements. Additionally, although no significant nonlinear relationships were found (all p > 0.05).

Conclusions: Thyroid dysfunction may impact postoperative outcomes in cardiac and major vascular surgery patients.

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甲状腺功能对心脏及大血管手术患者手术预后的影响。

目的：探讨心脏及大血管手术患者甲状腺功能与手术预后的关系。方法：对接受心脏或大血管手术的患者进行回顾性队列研究。评估术前甲状腺功能检查，包括TSH、游离T3和游离T4水平，以及术后甲状腺功能检查。记录并分析两组患者术后总住院时间、术后住院时间、ICU住院时间、机械通气时间等关键预后指标。分析方法包括Pearson相关、多变量logistic回归模型和限制三次样条。结果：本研究分析了472例接受各种心血管手术的患者，包括冠状动脉搭桥术（173例）、主动脉手术（131例）、瓣膜手术（125例）和原发性心脏肿瘤切除术（43例）。术前和术后甲状腺激素水平均有显著变化，TSH、FT3、FT4水平较术前显著降低（p < 0.05）。结论：甲状腺功能障碍可能影响心脏和大血管手术患者的术后预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.