Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-β_42:40 in Veterans.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-03-14 DOI:10.1177/13872877251321183

Meghan E Pierce, Mark Logue, Richard Sherva, Mark Miller, Bertrand R Huber, William Milberg, Jasmeet P Hayes

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引用次数: 0

Abstract

BackgroundIdentifying biomarkers of Alzheimer's disease (AD) is critical for early diagnosis and AD risk assessment.ObjectiveWe examined the hypothesis that the plasma amyloid-β 42 and 40 (Aβ_42:40) ratio has a curvilinear relationship with age among individuals who are at higher genetic risk for AD.MethodsThis study investigated the relationship between plasma amyloid-β 42 and 40 (Aβ_42:40) ratio and age in 315 men and women Veterans, including those at genetic risk for AD. Hierarchical regression models investigated linear and nonlinear relationships between age, genetic risk, and Aβ_42:40.ResultsWe observed a curvilinear relationship between age and Aβ_42:40 in individuals with higher genetic risk, characterized by an increase in the Aβ_42:40 during midlife followed by a decrease in older age.ConclusionsThese findings highlight distinct patterns in Aβ metabolism among genetically predisposed individuals, suggesting that early metabolic shifts may play a role in the progression of AD. Understanding these nuanced changes is essential for refining the use of Aβ_42:40 ratio as a biomarker, potentially leading to more accurate risk stratification and earlier intervention strategies in AD.

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退伍军人阿尔茨海默病遗传风险与血浆淀粉样蛋白-β42:40年龄依赖性变化的关系

背景确定阿尔茨海默病（AD）的生物标志物对于早期诊断和AD风险评估至关重要。方法本研究调查了315名男性和女性退伍军人（包括有AD遗传风险者）的血浆淀粉样蛋白-β 42和40（Aβ42:40）比值与年龄之间的关系。结果我们观察到，在遗传风险较高的个体中，年龄与 Aβ42:40 之间存在曲线关系，其特点是 Aβ42:40 在中年时增加，在老年时减少。了解这些细微的变化对完善Aβ42:40比值作为生物标志物的应用至关重要，有可能导致更准确的AD风险分层和更早的干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.