Adenomatoid Tumor of the Liver with Prominent Admixed Cavernous Hemangioma-Like Vessels: An Exceptional Occurrence.

Abstract

Adenomatoid tumors are benign neoplasms of mesothelial phenotype, commonly found in the genital tracts. Hepatic adenomatoid tumors are extremely uncommon and can present diagnostic challenges, particularly when mixed with other histologic elements. Here we report an adenomatoid tumor with prominent admixed cavernous hemangioma-like vessels in the liver of a 58-year-old woman. Grossly, the tumor appeared as a pedunculated lesion on the hepatic surface with cystic spaces filled with blood. Microscopic examination revealed numerous blood vessels of varying sizes intermingled with anastomosing tubular structures lined by cuboidal epithelioid cells that were immunohistochemically positive for mesothelial markers. Areas of typical cavernous hemangioma were also present within the same lesion. To our knowledge, this tumor represents the first documented instance of an adenomatoid tumor with prominent admixed cavernous hemangioma-like vessels in the liver. Our case report summarizes previously reported hepatic adenomatoid tumors and highlights their clinical, histopathologic, and immunohistochemical features. Given the various morphologic presentations, adenomatoid tumors can mimic other neoplasms. Their benign nature and excellent prognosis with complete surgical resection make accurate diagnosis crucial. Increased understanding and awareness of this uncommon tumor, combined with morphologic analysis and immunohistochemical studies, can help overcome diagnostic challenges to ensure accurate diagnosis and appropriate clinical management.