YAP1::MAML2 Fusion Positive Epithelioid Soft Tissue Neoplasms: A Case Report and Review of the Literature.

IF 0.9 4区医学 Q4 PATHOLOGY

International Journal of Surgical Pathology Pub Date : 2025-09-01 Epub Date: 2025-03-13 DOI:10.1177/10668969251323929

Claudia Grosse, Petar Noack, Alexandra Grosse

引用次数: 0

Abstract

In the recent literature soft tissue neoplasms which harbor a recurrent YAP1::MAML2 fusion and have an epithelioid morphology with resemblance to myxoinflammatory fibroblastic sarcoma (MIFS) have been reported. In a recent series these tumors had a nodular appearance and central necrosis and were termed nodular necrotizing variants of MIFS. But their exact relationship to MIFS and their biological behavior seem to be unclear. We report a YAP1::MAML2 fusion positive nodular and necrotizing tumor with a MIFS-like morphology and provide a review of the literature.

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YAP1::MAML2融合阳性上皮样软组织肿瘤1例报告及文献复习。

最近的文献报道了一些软组织肿瘤，这些肿瘤携带复发性 YAP1::MAML2 融合，具有上皮样形态，与肌炎性成纤维肉瘤（MIFS）相似。在最近的一系列研究中，这些肿瘤具有阳离子外观和中心坏死，被称为 MIFS 的结节性坏死变异型。但它们与 MIFS 的确切关系及其生物学行为似乎还不清楚。我们报告了一种YAP1::MAML2融合阳性、形态类似MIFS的结节性坏死性肿瘤，并对文献进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Surgical Pathology 医学-病理学

CiteScore

2.10

自引率

0.00%

发文量

198

审稿时长

1 months

期刊介绍： International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).