Joint examination of reflexive vertical saccades and small involuntary fixational saccades improves the classification of patients with progressive supranuclear palsy (PSP): a ROC study.

IF 1.7 4区 医学 Q4 NEUROSCIENCES
Wolfgang Becker, Olga Vintonyak, Jan Kassubek
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引用次数: 0

Abstract

A slowing of saccadic eye movements is one of the key symptoms of progressive supranuclear palsy and therefore represents a core functional domain of the current diagnostic criteria. However, there is considerable overlap between the saccade velocities of healthy people and patients in early stages. Therefore, a highly specific discrimination between patients and controls based on eye velocity often results in a considerable loss of sensitivity. Another symptom of progressive supranuclear palsy is a high frequency of square wave jerks formed by small involuntary fixational saccades. Using ROC analyses of 50 patients and 50 controls and focusing on points of 100 and 90% specificity or sensitivity, we investigated whether the velocity and gain data of visually guided reflexive saccades could be combined with each other and with parameters of fixational saccades to improve discriminability compared to considering saccade velocity alone. Both approaches were successful in patients with long disease duration but less so in cases of short duration. The displacement rate produced by square waves during fixation proved helpful because its frequency distributions in patients and controls had value ranges that were not shared by the two groups. This fact allowed an a priori classification of some subjects as either patients or controls. Modified ROC analyses using this a priori information are expected to work equally well in patients with short and long disease duration. In future studies it might be addressed if these methods can also improve the discrimination between PSP and other Parkinsonian disorders.

反身性垂直扫视和小的不自主固定扫视的联合检查改善了进行性核上性麻痹(PSP)患者的分类:一项ROC研究。
跳眼运动减慢是进行性核上性麻痹的关键症状之一,因此是当前诊断标准的核心功能领域。然而,健康人与早期患者的扫视速度有相当大的重叠。因此,基于眼速度对患者和对照组进行高度特异性的区分往往会导致相当大的灵敏度损失。进行性核上性麻痹的另一个症状是由小的不自主注视性扫视形成的高频方波抽搐。通过对50例患者和50例对照者的ROC分析,以特异性或敏感性分别为100%和90%的点为重点,我们探讨了视觉引导反射性扫视的速度和增益数据是否可以相互结合,并与注视性扫视参数相结合,相比单独考虑扫视速度,是否可以提高可辨性。这两种方法在病程长的患者中都是成功的,但在病程短的患者中则不太成功。在固定期间由方波产生的位移率被证明是有用的,因为其频率分布在患者和对照组中具有两组不共享的值范围。这一事实允许将一些受试者先验地分类为患者或对照组。使用此先验信息的修正ROC分析预计在病程短和病程长的患者中同样有效。在未来的研究中,如果这些方法也能提高PSP和其他帕金森病的区分,可能会得到解决。
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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
228
审稿时长
1 months
期刊介绍: Founded in 1966, Experimental Brain Research publishes original contributions on many aspects of experimental research of the central and peripheral nervous system. The focus is on molecular, physiology, behavior, neurochemistry, developmental, cellular and molecular neurobiology, and experimental pathology relevant to general problems of cerebral function. The journal publishes original papers, reviews, and mini-reviews.
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