Paper-based Microfluidics for Tissue Engineering and Regenerative Medicine.

IF 2.9 4区生物学 Q1 ANATOMY & MORPHOLOGY

Cells Tissues Organs Pub Date : 2025-03-13 DOI:10.1159/000545248

Jaehun Lee, Haoyue Luo, Yun-Ya Chen, Kirsten Ilestad, Dottie Yu, Mikayla Ybarra, Chao Ma

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引用次数: 0

Abstract

Background: Paper-based microfluidics have gained significant attention as cost-effective and biocompatible platforms for various biological and medical applications. These devices facilitate the replication of complex tissue environments and offer a versatile alternative to traditional microfluidic systems.

Summary: This review highlights recent advances in paper-based microfluidics for tissue engineering and regenerative medicine. Key applications include 3D cell culture, bioanalysis assays, and high-throughput screening systems. Innovations in fabrication methods, such as wax printing and inkjet printing, have enhanced the functionality and scalability of these devices. Furthermore, the integration of biomaterials and surface modification techniques has improved their utility in replicating physiological conditions and studying cellular behaviors. Challenges such as mechanical robustness, imaging compatibility, and immune antigenicity are also addressed, alongside potential solutions and future directions.

Key messages: Paper-based microfluidic systems provide a transformative platform for tissue engineering and regenerative medicine, offering simplicity, affordability, and functional versatility. With ongoing innovations, these devices are poised to bridge the gap between laboratory research and clinical applications, supporting advancements in personalized medicine, regenerative therapies, and disease modeling.

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用于组织工程和再生医学的纸基微流体技术。

背景：纸基微流体技术作为具有成本效益和生物兼容性的平台，在各种生物和医学应用中获得了极大的关注。这些设备有助于复制复杂的组织环境，是传统微流控系统的多功能替代品。摘要：本综述重点介绍了用于组织工程和再生医学的纸基微流控技术的最新进展。主要应用包括三维细胞培养、生物分析测试和高通量筛选系统。蜡打印和喷墨打印等制造方法的创新增强了这些设备的功能性和可扩展性。此外，生物材料和表面改性技术的整合提高了这些设备在复制生理条件和研究细胞行为方面的实用性。此外，还讨论了机械坚固性、成像兼容性和免疫抗原性等挑战，以及潜在的解决方案和未来发展方向：纸基微流体系统为组织工程和再生医学提供了一个变革性的平台，具有简便性、经济性和功能多样性。随着不断的创新，这些设备将在实验室研究和临床应用之间架起一座桥梁，为个性化医疗、再生疗法和疾病建模的发展提供支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cells Tissues Organs 生物-发育生物学

CiteScore

4.90

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Cells Tissues Organs'' aims at bridging the gap between cell biology and developmental biology and the emerging fields of regenerative medicine (stem cell biology, tissue engineering, artificial organs, in vitro systems and transplantation biology). CTO offers a rapid and fair peer-review and exquisite reproduction quality. Special topic issues, entire issues of the journal devoted to a single research topic within the range of interests of the journal, are published at irregular intervals.