Examining the roles of body composition, energy expenditure and substrate metabolism in the control of daily energy intake in adolescents with obesity.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-03-13 DOI:10.1038/s41366-025-01740-6

D Thivel, M Hopkins, S Lazzer, C Montaurier, H Moore, B Pereira, J E Blundell, L Isacco, Y Boirie

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引用次数: 0

Abstract

Background: The implication of body composition and energy metabolism in the control of human energy intake (EI) has been well described in adults, remaining however unexplored in adolescents with obesity. The aim of this study was to question the role of body composition, energy expenditure (EE) and substrate metabolism in the control of EI of adolescents with obesity.

Methods: Ad libitum 24-h EI, body composition (Dual X-ray absorptiometry), Resting Metabolic Rate (RMR, indirect calorimeter) where measured and Total EE obtained during a 36-h stay in metabolic chambers in 26 adolescents (14.1 ± 1.5 years; 14 girls) with severe obesity.

Results: The mean body weight and Body Mass index were 92.2 ± 17.2 kg and 33.98 ± 4.14 kg.m^-2 respectively. 24-h EI was positively correlated with body weight (rho = 0.597, p = 0.014), Fat Free Mass (FFM) kg (rho = 0.576, p = 0.019), 24-h Total EE (TEE (rho =0.675, p < 0.001)), RMR (rho =0.632, p = 0.005), 24-h Carbohydrate (CHO) oxidation rates (rho = 0.716, p < 0.001), and urinary nitrogen excretion (rho =0.28, p < 0.001). According to the path analysis FFM (kg) but not Fat Mass (FM) (kg) was positively correlated with RMR, with direct effects of 0.87 (p < 0.001) and 0.027 (p = 0.74) respectively. The effect of FFM on 24-h EI was mediated by RMR (96% of the effect), while the effect of FM on 24-h EI was also mediated by RMR (67% of the effect).

Conclusions: The present study provides the first evidence regarding the role of RMR as a main tonic signal of appetite control mediating the effect of body composition and mainly FFM (over FM) on daily EI in adolescents with obesity. It also suggests for the first-time relationships between 24-h CHO and protein oxidation and daily EI in this population.

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研究肥胖青少年的身体组成、能量消耗和底物代谢在控制每日能量摄入中的作用。

背景：身体组成和能量代谢在成人控制人体能量摄入（EI）中的意义已被很好地描述，但在青少年肥胖中仍未被探索。本研究的目的是探讨肥胖青少年身体成分、能量消耗（EE）和底物代谢在EI控制中的作用。方法：26例青少年（14.1±1.5岁）在代谢室中停留36小时，测量自由活动24小时EI、体成分（双x线吸收仪）、静息代谢率（RMR，间接量热仪）和总EE（总EE）。14名女孩)严重肥胖。结果：平均体重为92.2±17.2 kg，体质量指数为33.98±4.14 kg。m - 2。24小时EI与体重（rho = 0.597, p = 0.014）、无脂质量（FFM） kg （rho = 0.576, p = 0.019）、24小时总EE (TEE) （rho =0.675, p）呈正相关。结论：本研究首次证实了RMR作为食欲控制的主要补品信号，介导体成分对肥胖青少年日常EI的影响，主要是FFM（而非FM）的影响。这也首次提示了该人群24小时CHO与蛋白质氧化和每日EI之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.