Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1.

IF 2 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI:10.1080/1354750X.2025.2479664
Hiba A Yousif, Mohammed A Hami
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引用次数: 0

Abstract

Background and objective: Waterpipe smoking (WPS) has increased globally and may lead to various metabolic disorders. However, its long-term effects and cessation impact on metabolic biomarkers and omentin-1 remain unclear. This study aims to evaluate the impact of WPS and its cessation on metabolic biomarkers and omentin-1 levels and explore their correlations.

Materials and methods: 90 individuals were categorized into three groups (non-smokers, waterpipe smokers and cessation of waterpipe smokers). FBS and lipid profiles including TC, TG and HDL were measured using the Cobas 6000 c501 system, while FI was analyzed with the Cobas 6000 c601 system. Omentin-1 concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) with a human omentin ELISA kit.

Results: FI, HOMA-IR and lipid profiles were significantly elevated in WPS and cessation groups. Omentin-1 and DBP levels significantly decreased in both groups compared to non-smokers. Increased WPS duration leads to reduced BMI, WC and DBP, while cessation duration decreases FBS and SBP. A negative association was identified among omentin-1 with FBS and O2.

Conclusion: WPS and its cessation adversely affect metabolic health, reducing omentin-1 levels and increasing the risk of metabolic disorders. Over time, cessation improves specific biochemical markers, highlighting the need for public health awareness.

水烟吸烟及戒烟对代谢生物标志物及新的生物标志物网膜蛋白-1的影响
背景与目的:水烟吸烟(WPS)在全球范围内增加,并可能导致各种代谢紊乱。然而,其长期效果和戒烟对代谢生物标志物和网膜-1的影响尚不清楚。本研究旨在评估WPS及其停用对代谢生物标志物和网膜蛋白-1水平的影响,并探讨它们之间的相关性。材料与方法:将90人分为三组(非吸烟者、水烟吸烟者和戒烟者)。使用Cobas 6000 c501系统测量FBS和血脂,包括TC, TG和HDL,而使用Cobas 6000 c601系统分析FI。采用酶联免疫吸附试验(ELISA)和人网膜蛋白酶联免疫吸附测定试剂盒测定网膜蛋白-1浓度。结果:在WPS组和戒烟组中,FI、HOMA-IR和脂质谱显著升高。与不吸烟者相比,两组的Omentin-1和DBP水平均显著降低。WPS持续时间的增加导致BMI、WC和DBP的降低,而戒烟持续时间降低FBS和SBP。网膜蛋白-1与FBS和O2呈负相关。结论:WPS及其停止会对代谢健康产生不利影响,降低omentin-1水平,增加代谢紊乱的风险。随着时间的推移,戒烟改善了特定的生化指标,突出了公众卫生意识的必要性。
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来源期刊
Biomarkers
Biomarkers 医学-毒理学
CiteScore
5.00
自引率
3.80%
发文量
140
审稿时长
3 months
期刊介绍: The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.
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