[Translated article] Triglyceride-glucose Index as a Predictor of Cardiovascular Events in Psoriatic Patients on Systemic Therapy: A 150-patient Observational Study

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas Pub Date : 2025-05-01 DOI:10.1016/j.ad.2025.03.007

L. Fernández Domper , J.M. Martin Hernández , J.A. Páramo , L. Fernández Alonso , Á. Revert Fernández , M. Morales Suarez-Varela

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引用次数: 0

Abstract

Psoriasis is consistently associated with an elevated cardiovascular risk. However, biochemical parameters are needed to predict cardiovascular events in these patients. Therefore, we conducted a retrospective cohort study with psoriatic patients undergoing systemic treatment to analyze the value of the triglyceride-glucose (TyG) index in predicting the development of major adverse cardiovascular events (MACE). A total of 150 patients were selected, 12 of whom developed MACE (11 myocardial infarctions and one stroke) after a median follow-up of 17 months. The highest quartile of the TyG index was associated with a greater risk of developing MACE (HR, 9.3; 95%CI, 1.1–78.9). The predictive capabilities of the TyG index for predicting these events showed an area under the curve of 0.75 (0.60–0.90), p = 0.001. These results demonstrate that the TyG index could be useful in the early identification of psoriatic patients at high risk of developing MACE.

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作为银屑病患者心血管事件预测指标的甘油三酯-葡萄糖比值与系统治疗：一项针对 150 名患者的观察性研究。

牛皮癣一直与心血管风险升高有关。然而，需要生化参数来预测这些患者的心血管事件。因此，我们对接受全身治疗的银屑病患者进行回顾性队列研究，分析甘油三酯-葡萄糖（TyG）指数在预测主要心血管不良事件（MACE）发生中的价值。共选择150例患者，其中12例在中位随访17个月后发生MACE（11例心肌梗死和1例卒中）。TyG指数最高的四分位数与发生MACE的风险较高相关(HR, 9.3；95%可信区间,1.1 - -78.9)。TyG指数预测这些事件的曲线下面积（AUC）为0.75 (0.60 ~ 0.90),P = 0.001。这些结果表明，TyG指数可用于早期识别MACE高风险的银屑病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas dermo-sifiliograficas DERMATOLOGY-

CiteScore

1.90

自引率

9.40%

发文量

473

审稿时长

56 weeks

期刊介绍： Actas Dermo-Sifiliográficas, publicación Oficial de la Academia Española de Dermatología y Venereología, es una revista de prestigio consolidado. Creada en 1909, es la revista mensual más antigua editada en España.En 2006 entró en Medline, y hoy resulta imprescindible para estar al día sobre la dermatología española y mundial.