Combined Effect of Biological Age and Fine Particulate Matter Pollution with Risk of Non-Alcoholic Fatty Liver Disease in the UK Biobank: A Prospective Cohort Study.

IF 5 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American journal of epidemiology Pub Date : 2025-03-12 DOI:10.1093/aje/kwaf046

Xiaoqing Zhang, Pei Hai, Junjie Xue, Qiaozhen Cai, Jie Zhang, Junxi Zhang, Di Zhang, Youcai Tang, Yacong Bo, Quanjun Lyu

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引用次数: 0

Abstract

Background: Aging and long-term exposure to fine particulate matter (PM2.5) are associated with a higher risk of non-alcoholic fatty liver disease (NAFLD), but evidence on their combined effect is limited. We thus evaluated the joint effects of accelerated biological aging and PM2.5 exposure on incident NAFLD in a UK cohort.

Methods: We included 296,917 UK Biobank participants without NAFLD at baseline. Annual mean PM2.5 concentration was evaluated using a land use regression model. Biological age was assessed using the Klemera-Doubal method (KDM-BA) and PhenoAge algorithm. Cox proportional hazards models were used to assess the effects on incident NAFLD.

Results: Both chronic PM2.5 exposure and older biological age were linked to higher risk of NAFLD, with hazard ratios (HR) of 1.07 (95% CI 1.04-1.10) per SD increase in PM2.5, 1.47 (95% CI 1.43-1.52) in per SD increase KDM-BA, and 1.38 (95% CI 1.35-1.41) in per SD increase PhenoAge-BA, respectively. Participants with low PhenoAge and low PM2.5 had a lower NAFLD risk than those with high PhenoAge and high PM2.5. Positive additive interactions were observed.

Conclusions: This study suggests that both PM2.5 exposure and biological aging increase NAFLD risk, with simultaneous exposure to high levels potentially intensifying their effects.

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来源期刊

American journal of epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

4.00%

发文量

221

审稿时长

3-6 weeks

期刊介绍： The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research. It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.