Front Cover: Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells (ChemBioChem 6/2025)

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-03-14 DOI:10.1002/cbic.202580601

Thais Gazzi, Benjamin Brennecke, Valentas Olikauskas, Remo Hochstrasser, Haiyan Wang, Suzan Keen Chao, Kenneth Atz, Yelena Mostinski, Andreas Topp, Dominik Heer, Isabelle Kaufmann, Martin Ritter, Luca Gobbi, Benoit Hornsperger, Bjoern Wagner, Hans Richter, Fionn O'Hara, Matthias B. Wittwer, Dennis Jul Hansen, Ludovic Collin, Bernd Kuhn, Joerg Benz, Uwe Grether, Marc Nazaré

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Abstract

The histamine subtype 3 receptor (H₃R) is mainly expressed in the brain, where it plays a key role in various neurological functions. This brain imaging, featuring glowing neural connections, highlights the high expression of H₃R. The molecular structure approaching the brain represents new Positron Emission Tomography (PET) probes for precise brain imaging. The light trail indicates the potential of this PET probe to visualize H₃R, providing insights into brain function and pathology. More details can be found in Research Article 10.1002/cbic.202400704 by Magnus Schou, Steven H Liang, and co-workers.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).