Cover Feature: Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na+/K+ Transporting Subunit Alpha 1 (ATP1A1) (ChemBioChem 6/2025)

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-03-14 DOI:10.1002/cbic.202580602

Ryosuke Katsumata, Hiroshi Kamiyama, Koji Sagane, Yuji Yamamoto, Hiroshi Azuma, Kyoko Nishibata, Yoshihiko Kotake, Shizuka Nakano, Shinya Okubo, Toshiaki Teruya, Akifumi Okuda, Yasutaka Takase

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Abstract

Odoamide, a member of aurilide-family, exhibits highly potent cytotoxicity against cancer cells lines. The background scenery is Odohama Beach in Okinawa, Japan, where odoamide was isolated. Three key points are shown above: affinity-based target identification, the target protein, and phenotype of cytotoxicity. These findings will provide target identification technologies and critical information on the subsequent mechanistic analysis as well, which has been under discussion for years. More details can be found in article 10.1002/cbic.202400762 by Ryosuke Katsumata, Hiroshi Kamiyama, Yasutaka Takase, and co-workers.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).