Treatment for Depression Among Adults: An Evidence and Gap Map of Systematic Reviews

IF 3.6 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Liping Guo, Junjie Ren, Zhipeng Wei, Xinyu Huang, Nina Dela Cruz, Leonor Rodriguez Estrada, Zhichun Zhang, Howard White, Kehu Yang
{"title":"Treatment for Depression Among Adults: An Evidence and Gap Map of Systematic Reviews","authors":"Liping Guo,&nbsp;Junjie Ren,&nbsp;Zhipeng Wei,&nbsp;Xinyu Huang,&nbsp;Nina Dela Cruz,&nbsp;Leonor Rodriguez Estrada,&nbsp;Zhichun Zhang,&nbsp;Howard White,&nbsp;Kehu Yang","doi":"10.1111/jebm.70011","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To identify and map systematic reviews on the effectiveness of treatment for depressive disorders among adults.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We retrieved systematic reviews and meta-analyses of randomized controlled trials involving adults with depressive symptoms from twelve English and four Chinese databases (June 21, 2022). Using an interactive map, we visualized the effectiveness of evidence on depression based on an intervention-outcome framework. The interventions included psychotherapy, pharmacotherapy, complementary and alternative treatments, and others. The outcomes included the remission of depressive symptoms, symptoms of depressive disorder, life and social skills, and adverse events.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We included 994 systematic reviews and meta-analyses, including 32 that were review protocols, highlighting the distribution of psychotherapy, pharmacotherapy, and complementary and alternative treatments. However, the evidence and gap map (EGM) revealed significant gaps in evidence for specific interventions, populations, outcomes, and regions. While psychotherapy, pharmacotherapy, and complementary and alternative treatments dominate the landscape, the review highlighted a lack of research on interventions for specific types of depression, such as depression in people with bipolar disorder and treatment-resistant depression. It was a similar situation for underserved populations, including young and middle-aged adults, males, sexual minority individuals, and people with disabilities. The map also suggested the need for more research on the potential risks and side effects associated with both pharmacological and nonpharmacological treatments.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The contribution of this EGM was to present the available evidence on psychotherapy, pharmacotherapy, and complementary and alternative treatments for depression in adults, making available an evidence base that could inform future policy decisions and practice. It also identified evidence gaps in interventions, outcomes, population, regions, and evidence confidence. The need for further research on tailored treatments for specific populations was highlighted.</p>\n </section>\n </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evidence‐Based Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jebm.70011","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective

To identify and map systematic reviews on the effectiveness of treatment for depressive disorders among adults.

Methods

We retrieved systematic reviews and meta-analyses of randomized controlled trials involving adults with depressive symptoms from twelve English and four Chinese databases (June 21, 2022). Using an interactive map, we visualized the effectiveness of evidence on depression based on an intervention-outcome framework. The interventions included psychotherapy, pharmacotherapy, complementary and alternative treatments, and others. The outcomes included the remission of depressive symptoms, symptoms of depressive disorder, life and social skills, and adverse events.

Results

We included 994 systematic reviews and meta-analyses, including 32 that were review protocols, highlighting the distribution of psychotherapy, pharmacotherapy, and complementary and alternative treatments. However, the evidence and gap map (EGM) revealed significant gaps in evidence for specific interventions, populations, outcomes, and regions. While psychotherapy, pharmacotherapy, and complementary and alternative treatments dominate the landscape, the review highlighted a lack of research on interventions for specific types of depression, such as depression in people with bipolar disorder and treatment-resistant depression. It was a similar situation for underserved populations, including young and middle-aged adults, males, sexual minority individuals, and people with disabilities. The map also suggested the need for more research on the potential risks and side effects associated with both pharmacological and nonpharmacological treatments.

Conclusions

The contribution of this EGM was to present the available evidence on psychotherapy, pharmacotherapy, and complementary and alternative treatments for depression in adults, making available an evidence base that could inform future policy decisions and practice. It also identified evidence gaps in interventions, outcomes, population, regions, and evidence confidence. The need for further research on tailored treatments for specific populations was highlighted.

成人抑郁症的治疗:系统评价的证据和差距图
目的对成人抑郁症的治疗效果进行系统评价。方法我们从12个英文和4个中文数据库(2022年6月21日)中检索了涉及成人抑郁症状的随机对照试验的系统综述和荟萃分析。使用交互式地图,我们将基于干预-结果框架的抑郁症证据的有效性可视化。干预措施包括心理治疗、药物治疗、补充和替代治疗等。结果包括抑郁症状的缓解、抑郁障碍的症状、生活和社交技能以及不良事件。结果我们纳入了994项系统综述和荟萃分析,其中32项是综述方案,强调了心理治疗、药物治疗、补充和替代治疗的分布。然而,证据和差距图(EGM)显示了具体干预措施、人群、结果和地区的证据存在显著差距。虽然心理疗法、药物疗法以及补充和替代疗法占主导地位,但该综述强调,缺乏对特定类型抑郁症的干预研究,例如双相情感障碍患者的抑郁症和治疗难治性抑郁症。对于服务不足的人群,包括青壮年、男性、性少数群体和残疾人,情况也类似。该地图还表明,需要对药物和非药物治疗的潜在风险和副作用进行更多的研究。该EGM的贡献在于提供了关于成人抑郁症的心理治疗、药物治疗以及补充和替代治疗的现有证据,为未来的政策决策和实践提供了证据基础。它还确定了干预措施、结果、人口、地区和证据可信度方面的证据差距。会议强调有必要进一步研究针对特定人群的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Evidence‐Based Medicine
Journal of Evidence‐Based Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
11.20
自引率
1.40%
发文量
42
期刊介绍: The Journal of Evidence-Based Medicine (EMB) is an esteemed international healthcare and medical decision-making journal, dedicated to publishing groundbreaking research outcomes in evidence-based decision-making, research, practice, and education. Serving as the official English-language journal of the Cochrane China Centre and West China Hospital of Sichuan University, we eagerly welcome editorials, commentaries, and systematic reviews encompassing various topics such as clinical trials, policy, drug and patient safety, education, and knowledge translation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信