Solitary oral paracoccidioidomycosis without pulmonary symptoms: a case report

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.075

Juan Martin Pimentel Sola, Ignacio Molina Avila, Ruth Valdez, Yone Chacon, Gerardo Gilligan

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引用次数: 0

Abstract

To present a rare clinical case of oral Paracoccidioidomycosis without pulmonary symptoms, emphasizing the clinical challenge to diagnose deep mycosis in dental practice. We report a case of a 37-year-old unemployed male patient from Tartagal, Salta, referred to the Stomatology Unit of Hospital Señor del Milagro due to a 3-month history of ulcerative lesions on the lower lip, upper lip, and left buccal mucosa. The clinical hypothesis was a malignant lesion (oral squamous cell carcinoma). A fresh sample was obtained for Giemsa staining, an incisional biopsy was performed for histopathological examination with PAS staining, and a chest X-ray was suggested. The final diagnosis was Oral Paracoccidioidomycosis. The patient was treated with intravenous amphotericin B 50 mg every 24 hours for 10 days, followed by oral itraconazole 200 mg every 12 hours for 9 months. Correct diagnosis of this fungal infection is crucial, emphasizing interdisciplinary collaboration among different specialties.

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无肺部症状的孤立性口腔副球孢子菌病1例报告

报告一例罕见的无肺部症状的口腔副球孢子菌病，强调在牙科实践中诊断深部真菌病的临床挑战。我们报告一例来自萨尔塔州Tartagal的37岁无业男性患者，由于3个月的下唇、上唇和左颊粘膜溃疡病变史，他被转介到Señor del Milagro医院口腔科。临床假设为恶性病变（口腔鳞状细胞癌）。取新鲜标本进行吉姆萨染色，行切口活检进行组织病理学检查，PAS染色，并建议进行胸部x线检查。最终诊断为口腔副球孢子菌病。患者静脉滴注两性霉素B 50 mg / 24 h，连续10天，随后口服伊曲康唑200 mg / 12 h，连续9个月。正确诊断这种真菌感染是至关重要的，强调不同专业之间的跨学科合作。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.