Simultaneous presentation of peripheral ossifying fibroma and pyogenic granuloma: a case report

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.087

Michele Di Benedetto, Lukas Mendes de Abreu, Kaique Alberto Preto, Raquel Molina Sanches, Vanessa Soares Lara, Paulo Sérgio da Silva Santos, Cássia Maria Fischer Rubira

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Abstract

Peripheral Ossifying Fibroma (POF) and Pyogenic Granuloma (PG) are common reactive lesions in the oral cavity, presenting distinct histomorphological characteristics. We report a case of a 54-year-old female patient with a singular lesion on the left posterior gingiva of the mandible. The lesion had been evolving for 8 months and presented painful symptoms. Excisional biopsy was performed, and histopathological analysis revealed fibrous connective tissue with high cellularity, spindle-shaped cells, and mineralized tissue resembling trabecular bone, alongside indications of chronic periodontal inflammation and granulation tissue. The diagnosis was peripheral ossifying fibroma associated with pyogenic granuloma and chronic inflammatory periodontal disease. Such concurrent occurrence and interrelation are rarely documented in the literature. This case underscores the significance of accurate differential diagnosis and understanding the etiopathogenic foundations of these lesions to ensure proper clinical management.

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同时表现为周围骨化性纤维瘤和化脓性肉芽肿1例

周围骨化性纤维瘤（POF）和化脓性肉芽肿（PG）是口腔常见的反应性病变，具有不同的组织形态学特征。我们报告了一例 54 岁女性患者的病例，她的下颌骨左后方牙龈出现单发病变。病变已持续发展 8 个月，并伴有疼痛症状。患者接受了切除活检，组织病理学分析显示病变为纤维结缔组织，具有高细胞度、纺锤形细胞和类似骨小梁的矿化组织，同时还显示有慢性牙周炎症和肉芽组织。诊断结果为外周骨化性纤维瘤伴化脓性肉芽肿和慢性炎症性牙周病。这种并发症和相互关系在文献中很少见。该病例强调了准确鉴别诊断和了解这些病变的病因基础对确保正确临床治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.