Okeke Chinedu , Isa Alkali Hezekiah , Oyetunde Bankole Akinloye , Asala Samuel , Akinyemi Olugbenga Ofakunrin , Oche Patrick Ogbe , Rose Amaechi , Obiageli Eunice Nnodu
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引用次数: 0
Abstract
Background
One of the components of comprehensive care and interventions in managing patients with sickle cell disease (SCD) is red blood cell transfusion. This has helped in reducing the morbidity and mortality associated with SCD. Individuals who undergo multiple red cell transfusions are faced with alloimmunization which makes it difficult to source compatible blood for them. This often leads to haemolytic reactions and sometimes death of the patients. In this study, we determined the prevalence and pattern of alloimmunization in patients with SCD.
Methods
This was a cross-sectional study of 205 patients with SCD aged 1–45 years, attending the sickle cell clinic at the University of Abuja Teaching Hospital, Gwagwalada, Abuja. Antibody detection and identification were done using the tube technique (Lone Laboratories UK). The data was analyzed and reported in percentages and descriptive statistics.
Results
Of the 205 participants, 115 (56.1 %) were males while 90 (43.9 %) were females. 99 (48.8 %) of the patients had been transfused two or more times while 49(23.9 %) were transfused only once. Fifty-seven (27.8 %) participants have never had a transfusion. The following blood group systems were observed in 26 alloimmunized SCD participants; Rh (D/E/e/C/Cw) 46 %, Kell19.2 %, Lewis 11.5 %, MNS 3.8 %, Duffy 23.0 %. All 26 participants have had more than one episode of blood transfusion.
Conclusion
The prevalence rate was 17.6 % and Rh alloantibodies were common among patients with SCD who have received multiple transfusions. Proper blood detection and identification of alloantibodies should be promoted before blood transfusion to manage these patients better.
期刊介绍:
Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues.
Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.