Diverse case series of granulomatous peritonitis mimicking advanced ovarian cancer

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2025-03-07 DOI:10.1016/j.gore.2025.101712

Rachel L. Furuya , Bobbie J. Rimel , Richard Tsai , Rebecca Ann Brooks , L. Stewart Massad , Premal H. Thaker , John D. Pfeifer

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引用次数: 0

Abstract

Background

Epithelial ovarian cancer commonly presents with vague symptoms that delay diagnosis until disease is advanced. Granulomatous peritonitis is a term used to describe granulomatous inflammation within the peritoneal cavity and mimics advanced stage ovarian cancer clinically and on imaging. The goal of this study was to examine the frequency and characteristics of cases of granulomatous peritonitis mimicking ovarian cancer at a single institution and to describe the etiology in this population.

Methods

Eight cases were identified with pathology conformation of granulomatous disease and absence of cancer. The etiologies include pelvic tuberculosis, ruptured dermoid cyst, ruptured hemorrhagic corpus luteum, prior endometriosis surgery, xanthogranulomatous inflammation and three cases of tubo-ovarian abscesses.

Results

Seven of the eight had pelvic masses on imaging studies; one patient had presumed carcinomatosis without an adnexal mass on CT scan. Preoperative CA-125 was elevated in four of the eight patients, with a range of 30.8 to 228 U/mL. All had some form of surgical management with at least one ovary removed.

Conclusion

Clinicians should be aware of this disease to improve diagnosis and direct appropriate patient management.

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模拟晚期卵巢癌的肉芽肿性腹膜炎的不同病例系列

背景上皮性卵巢癌通常表现出模糊的症状，直到疾病进展才诊断。肉芽肿性腹膜炎是一个术语，用于描述腹膜腔内的肉芽肿性炎症，在临床和影像学上模仿晚期卵巢癌。本研究的目的是检查单个机构中类似卵巢癌的肉芽肿性腹膜炎病例的频率和特征，并描述该人群的病因。方法8例肉芽肿病病理表现为肉芽肿性疾病，无肿瘤。病因包括盆腔结核、皮样囊肿破裂、出血性黄体破裂、既往子宫内膜异位症手术、黄色肉芽肿性炎症和3例输卵管卵巢脓肿。结果8例患者中有7例影像学检查发现盆腔肿块；1例患者CT扫描未见附件肿块，推定为癌。8例患者中有4例术前CA-125升高，范围为30.8 ~ 228 U/mL。所有患者都进行了某种形式的手术治疗，至少切除了一个卵巢。结论临床医师应提高对本病的认识，提高诊断水平，指导合理的患者治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.