Large myofibroma in the mandible of an adult woman: a case report

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.028

Caroline Alfaia-Silva, José Renato Brandão, Tulio Silva Rosa, Filipe Modolo Siqueira, Elena Riet Correa Rivero, Rogério de Oliveira Gondak, Ricardo Luiz Cavalcanti de Albuquerque-Júnior

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引用次数: 0

Abstract

The myofibroma is a benign mesenchymal neoplasm of perivascular myoid cells that forms a spectrum with myopericytoma. We report the case of a 39-year-old woman with a unilocular radiolucent lesion in the mandible, extending from the mesial of the left first molar to near the incisura. Computed tomography showed a well-defined hypodense lesion. Incisional biopsy revealed a biphasic proliferation of round to spindle-shaped cells, with various fascicular patterns and narrow blood vessels surrounded by tumor cells. The stroma was predominantly myxoid, with low mitotic activity. Adjacent to the lesion, densely collagenized fibrous connective tissue, peripheral nerve fibers, and fragments of mucoserous acini from salivary glands were observed. Immunohistochemistry was positive for SMA and podoplanin. The diagnosis of myofibroma was established, highlighting its histological morphology and adjacent characteristics. Intraosseous myofibroma requires meticulous clinical-histological-radiological investigation, combined with an immunohistochemical marker panel, aiding in its diagnosis. The patient is awaiting tumor removal.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.