Epithelioid hemangioendothelioma of the oral cavity: case report

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.027

Lara Maria Alencar Ramos Innocentini, Isabella Cristine dos Santos, Ana Carolina Fragoso Motta, Hilton Marcos Alves Hicz, Alan Grupioni Lourenço, Joel Del Bel Padua, Leandro Dorigan de Macedo

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Abstract

A 49-year-old female was referred to a stomatologist due to complaints of enlargement and pain associated with a vascular lesion that had been monitored for 2 years. Her medical history revealed no systemic diseases. During the intraoral examination, a blue-purplish nodule was observed on the oral mucosa of the right lower lip and exhibited a fibrous region upon palpation with 1.0 cm in its greatest dimension. An incisional biopsy was performed, and histopathological examination revealed the presence of cords or nests of polygonal to slightly spindled epithelioid cells, with the formation of intracytoplasmic lumina, surrounding small vessels with perineural infiltration. Immunohistochemistry markers were positive for CD34, CD31, factor VIII-related antigen (FVIIIRAg), FLI1, D2-40, and ERG, confirming the diagnosis of epithelioid hemangioendothelioma (EHE). The patient was referred to a head and neck surgeon for complete removal of the EHE. She has been under observation for 2 years with no signs of recurrence.

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口腔上皮样血管内皮瘤1例

一名49岁女性因血管病变引起的肿大和疼痛就诊于口腔医生，该患者已监测2年。病史显示无全身性疾病。口腔内检查时，右下唇口腔黏膜见一蓝紫色结节，触诊后呈纤维区，最大尺寸为1.0 cm。行切口活检，组织病理学检查显示存在多边形至微梭形上皮样细胞的索状或巢状，并形成胞浆内腔，周围有神经周围浸润的小血管。免疫组化标志物CD34、CD31、因子viii相关抗原（FVIIIRAg）、FLI1、D2-40、ERG阳性，诊断为上皮样血管内皮瘤（EHE）。患者被转介给头颈部外科医生以完全切除EHE。患者观察2年，无复发迹象。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.