Rapidly growing pediatric rhabdomyosarcoma: clinical, tomographic and histological aspects

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.039

Livian Isabel de Medeiros Carvalho, Eduarda Gomes Onofre de Araújo, Hélder Domiciano Dantas Martins, Keila Martha Amorim Barroso, Amanda Maria Medeiros de Araújo Luck, Alexandre Rolim de Paz, Paulo Rogério Ferreti Bonan

{"title":"Rapidly growing pediatric rhabdomyosarcoma: clinical, tomographic and histological aspects","authors":"Livian Isabel de Medeiros Carvalho, Eduarda Gomes Onofre de Araújo, Hélder Domiciano Dantas Martins, Keila Martha Amorim Barroso, Amanda Maria Medeiros de Araújo Luck, Alexandre Rolim de Paz, Paulo Rogério Ferreti Bonan","doi":"10.1016/j.oooo.2025.01.039","DOIUrl":null,"url":null,"abstract":"<div><div>An 8-year-old female exhibited swelling after a tooth extraction, prompted by severe mobility of deciduous teeth and a tissue mass. The extraoral examination displayed significant swelling on the right side of the face, causing noticeable asymmetry. An intraoral examination uncovered a lobulated, erythematous tumor-like lesion. Panoramic radiography showed a radiolucent area in the right maxillary region, indicating a “floating teeth” pattern and root resorption. Computed tomography revealed an ill-defined hypodense mass extending to the orbit, nasal fossa, and right maxillary sinus. An incisional biopsy identified a proliferation of atypical round and spindle cells within a variably myxoid or fibrous stroma. Immunohistochemistry tests for desmin, myogenin, and the MYOD1 gene were positive, confirming a diagnosis of rhabdomyosarcoma. Following the diagnosis, the patient underwent radiotherapy and chemotherapy. Eight months into treatment, there has been no recurrence of the lesion, and she remains under careful observation.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e7"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440325000422","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

An 8-year-old female exhibited swelling after a tooth extraction, prompted by severe mobility of deciduous teeth and a tissue mass. The extraoral examination displayed significant swelling on the right side of the face, causing noticeable asymmetry. An intraoral examination uncovered a lobulated, erythematous tumor-like lesion. Panoramic radiography showed a radiolucent area in the right maxillary region, indicating a “floating teeth” pattern and root resorption. Computed tomography revealed an ill-defined hypodense mass extending to the orbit, nasal fossa, and right maxillary sinus. An incisional biopsy identified a proliferation of atypical round and spindle cells within a variably myxoid or fibrous stroma. Immunohistochemistry tests for desmin, myogenin, and the MYOD1 gene were positive, confirming a diagnosis of rhabdomyosarcoma. Following the diagnosis, the patient underwent radiotherapy and chemotherapy. Eight months into treatment, there has been no recurrence of the lesion, and she remains under careful observation.

查看原文本刊更多论文

快速生长的小儿横纹肌肉瘤：临床、断层和组织学方面

一名8岁女性在拔牙后出现肿胀，原因是乳牙严重移动和组织肿块。口腔外检查显示右侧面部明显肿胀，造成明显的不对称。口腔内检查发现分叶状红斑肿瘤样病变。全景x线摄片显示右侧上颌区一透光区，提示“浮牙”模式和牙根吸收。计算机断层扫描显示一个界限不清的低密度肿块，延伸到眼眶、鼻窝和右上颌窦。切口活组织检查发现不典型的圆形和梭形细胞在可变黏液或纤维间质内增生。免疫组化测试促球蛋白、肌原蛋白和MYOD1基因阳性，证实诊断为横纹肌肉瘤。确诊后，患者接受了放疗和化疗。治疗八个月后，病灶没有复发，她仍在仔细观察中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.