RFC and VDR -mediated genetic regulation of brain folate transport in patients with multiple sclerosis

IF 0.5 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2025-03-08 DOI:10.1016/j.humgen.2025.201399

Oleksandra Skavinska , Zoia Rossokha , Liliia Fishchuk , Natalia Gorovenko

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引用次数: 0

Abstract

Background

Genes controlling folate metabolism and their transport may become a new therapeutic target in the treatment of multiple sclerosis, as folates play an important role in the regeneration of myelin structures and regulation of methylation processes.

Objective

analysis of data on the state of functional activity of the RFC and VDR genes involved in the transport of folates into the brain in patients with multiple sclerosis and their impact on the development and progression of the disease.

Methods

An evaluation of modern literary sources devoted to the role of VDR and RFC genes was carried out in folate metabolism in the brain. The search was conducted in Scopus, Web of Science and PubMed databases.

Results

RFC plays an important role in the transport of folates, which is essential for neuroprotection in patients with multiple sclerosis. The interaction between VDR and RFC can regulate the expression of folate transporters, which affects the clinical course of the disease. The importance of vitamin D and folate in MS therapy indicates the need for further research to develop new treatment strategies.

Conclusion

Further research in this area may help develop new approaches to treating and maintaining the health of patients.

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多发性硬化症患者脑叶酸转运的RFC和VDR介导的遗传调控

叶酸在髓鞘结构再生和甲基化过程中发挥重要作用，因此控制叶酸代谢及其转运的基因可能成为多发性硬化症治疗的新靶点。目的分析多发性硬化症患者叶酸转运到大脑的RFC和VDR基因的功能活性状态及其对疾病发生和进展的影响。方法对VDR和RFC基因在脑叶酸代谢中的作用的现代文献资料进行评价。检索在Scopus、Web of Science和PubMed数据库中进行。结果rfc在叶酸转运中发挥重要作用，叶酸对多发性硬化症患者的神经保护至关重要。VDR和RFC的相互作用可以调节叶酸转运蛋白的表达，从而影响疾病的临床病程。维生素D和叶酸在多发性硬化症治疗中的重要性表明需要进一步研究以开发新的治疗策略。结论该领域的进一步研究将为治疗和维护患者健康提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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