Role of the premotor and the precentral negative motor area in praxis: A direct electrical stimulation study with behavioral analysis

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-03-10 DOI:10.1016/j.clinph.2025.03.008

Masaya Togo , Riki Matsumoto , Akihiro Shimotake , Tamaki Kobayashi , Takuro Nakae , Katsuya Kobayashi , Kiyohide Usami , Takayuki Kikuchi , Kazumichi Yoshida , Masao Matsuhashi , Takeharu Kunieda , Susumu Miyamoto , Ryosuke Takahashi , Akio Ikeda

{"title":"Role of the premotor and the precentral negative motor area in praxis: A direct electrical stimulation study with behavioral analysis","authors":"Masaya Togo , Riki Matsumoto , Akihiro Shimotake , Tamaki Kobayashi , Takuro Nakae , Katsuya Kobayashi , Kiyohide Usami , Takayuki Kikuchi , Kazumichi Yoshida , Masao Matsuhashi , Takeharu Kunieda , Susumu Miyamoto , Ryosuke Takahashi , Akio Ikeda","doi":"10.1016/j.clinph.2025.03.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Although the negative motor area (NMA) is defined as the area where electrical cortical stimulation inhibits voluntary movements, detail functions of NMA on praxis have not been elucidated. We investigated its role in praxis by motion analysis during stimulation at a smaller intensity.</div></div><div><h3>Methods</h3><div>Patients were six intractable partial epilepsy patients undergoing implantation of intracranial electrodes. Motion impairments by stimulation were studied in finger tapping, reach-to-grasp, finger gesture, and pantomime of tool use.</div></div><div><h3>Results</h3><div>NMAs were identified on the precentral gyrus (4 patients), ventral premotor area (1), and at their border (1). In patients with precentral NMA, quantitative analysis revealed decreased tapping stroke and grasping aperture, while reaching velocity and pantomime did not change. As for more rostral NMA, quantitative stroke, aperture, and reaching velocity were decreased. One patient showed the arrest of finger gestures and pantomime, and the other had prolongation of reaction time. These two NMAs showed distinct connectivity pattern in connectivity analysis.</div></div><div><h3>Conclusions</h3><div>Precentral NMA seemed to play a role in elementary finger movement control, whereas more rostral NMA in complex movement. The findings indicate functional differences within NMAs. Significance: These findings elucidated the contribution of the human premotor area to the highly skilled hand movements.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 66-75"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138824572500313X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Although the negative motor area (NMA) is defined as the area where electrical cortical stimulation inhibits voluntary movements, detail functions of NMA on praxis have not been elucidated. We investigated its role in praxis by motion analysis during stimulation at a smaller intensity.

Methods

Patients were six intractable partial epilepsy patients undergoing implantation of intracranial electrodes. Motion impairments by stimulation were studied in finger tapping, reach-to-grasp, finger gesture, and pantomime of tool use.

Results

NMAs were identified on the precentral gyrus (4 patients), ventral premotor area (1), and at their border (1). In patients with precentral NMA, quantitative analysis revealed decreased tapping stroke and grasping aperture, while reaching velocity and pantomime did not change. As for more rostral NMA, quantitative stroke, aperture, and reaching velocity were decreased. One patient showed the arrest of finger gestures and pantomime, and the other had prolongation of reaction time. These two NMAs showed distinct connectivity pattern in connectivity analysis.

Conclusions

Precentral NMA seemed to play a role in elementary finger movement control, whereas more rostral NMA in complex movement. The findings indicate functional differences within NMAs. Significance: These findings elucidated the contribution of the human premotor area to the highly skilled hand movements.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.