Traditional Chinese medicine in treating pox: Insights for basic and clinical research of Mpox

Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-03-11 DOI:10.1016/j.prmcm.2025.100602

Mei Lu , Yi Ying , Luming Xia , Lu Gao , Quangang Xu , Yi Zhang

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Abstract

Introduction

Mpox is rapidly spreading, posing a significant threat to public health. However, we were not prepared to deal with this re-emerging infectious disease. Traditional Chinese medicine (TCM) has long been used to treat emerging infectious diseases in China. It is worth investigating and debating whether TCM is a viable therapy option for mpox. This review aims to primarily describe the clinical evidence of TCM in the treatment of the pox virus, as well as the related antiviral mechanisms, to explore the potential of TCM in the treatment of mpox.

Methods

A comprehensive literature search was conducted to identify relevant studies on the use of TCM in treating poxvirus infections. Clinical trials, case reports, and mechanistic studies were included. Data on the effectiveness of TCM treatments, as well as the molecular and cellular mechanisms of action, were extracted and analyzed.

Results

Clinical evidence shows that TCM has considerable clinical effectiveness against poxvirus. TCM-derived medicinal compounds such as mimosine, quercetin, and miRNAs could inhibit viral replication by targeting viral genes or enzymes. TCMs have the benefit of being multitarget, multipathway, and multicomponent in the treatment of poxvirus. Furthermore, a number of TCM-prospective medications for the treatment of mpox were disclosed.

Discussion

The results suggest that TCM has enormous potential in the treatment of mpox. The multitarget and multipathway nature of TCM offers a unique advantage in combating complex viral infections. However, there are existing problems such as the lack of standardized TCM preparations and the need for more rigorous clinical trials. Initiatives for improved drug development should focus on standardization and validation of TCM treatments. Overall, this review provides theoretical guidance for future TCM research on mpox therapy, and it is likely to inspire research on a potential avenue of drug discovery for mpox treatment. Further studies are needed to fully realize the potential of TCM in the treatment of mpox.

Abstract Image